ABC1 Antibody (AB.H10): sc-58219

ABC1 Antibody (AB.H10) is a mouse monoclonal IgG1 antibody that detects ABC1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). ABC1 (AB.H10) antibody is available as the non-conjugated form. ABC1 protein, also known as ATP-binding cassette transporter 1, plays a crucial role in lipid metabolism by facilitating the efflux of cholesterol and phospholipids from cells, which is vital for maintaining cellular homeostasis and preventing the accumulation of lipids that can lead to atherosclerosis. ABC1 protein is predominantly located in the plasma membrane of various cell types, including macrophages, where ABC1 is essential for the formation of high-density lipoprotein (HDL) and the regulation of cholesterol levels in the body. Mutations in the ABC1 gene are associated with Tangier disease, a condition characterized by severely low levels of HDL cholesterol, underscoring the importance of ABC1 in cardiovascular health. ABC1 is widely expressed in human tissues, with particularly high levels found in the liver, lung, adrenal glands, placenta, and fetal tissue, and ABC1 expression is induced during monocyte differentiation and upregulated in the presence of acetylated low-density lipoprotein. ABC1 may also have a dual regulatory function in macrophage lipid metabolism and inflammation, making ABC1 a significant target for research in metabolic disorders and cardiovascular diseases.

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ABC1 Antibody (AB.H10) References:

1. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1.  |  Rust, S., et al. 1999. Nat Genet. 22: 352-5. PMID: 10431238
2. Human ATP-binding cassette transporter 1 (ABC1): genomic organization and identification of the genetic defect in the original Tangier disease kindred.  |  Remaley, AT., et al. 1999. Proc Natl Acad Sci U S A. 96: 12685-90. PMID: 10535983
3. Scavenger receptor-BI inhibits ATP-binding cassette transporter 1- mediated cholesterol efflux in macrophages.  |  Chen, W., et al. 2000. J Biol Chem. 275: 30794-800. PMID: 10896940
4. Structure, function and regulation of the ABC1 gene product.  |  Schmitz, G. and Langmann, T. 2001. Curr Opin Lipidol. 12: 129-40. PMID: 11264984
5. ATP-binding cassette transporter 1 attenuates ovalbumin-induced neutrophilic airway inflammation.  |  Dai, C., et al. 2014. Am J Respir Cell Mol Biol. 51: 626-36. PMID: 24813055
6. ATP-binding cassette transporter 1 (ABCA1) deficiency decreases platelet reactivity and reduces thromboxane A2 production independently of hematopoietic ABCA1.  |  Lhermusier, T., et al. 2016. J Thromb Haemost. 14: 585-95. PMID: 26749169
7. Restoring AIBP expression in the retina provides neuroprotection in glaucoma.  |  Ju, WK., et al. 2023. bioRxiv.. PMID: 37905114
8. ABC transporter-facilitated ATP conductive transport.  |  Schwiebert, EM. 1999. Am J Physiol. 276: C1-8. PMID: 9886914

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ABC1 Antibody (AB.H10) has 48 citations in a variety of scientific publications.

Primary antibodies like Anti-ABC1 Antibody (AB.H10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ABC1 Antibody (AB.H10) Specifications

Alternate Product Name: ABCA1

Product Clone Name: AB.H10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 1800-2260

Epitope Target: ABC1

Epitope Species: human

Product Reactivity/Detection: ABC1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 48 citations in various scientific publications

Available Conjugates/Forms for ABC1 Antibody (AB.H10): N/A