STAC Antibody (J-19): sc-100661

STAC Antibody (J-19) is a mouse monoclonal IgG1 kappa light chain antibody that detects the STAC protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-STAC antibody (J-19) is available as a non-conjugated format. STAC protein, also known as SH3 and cysteine-rich domain-containing protein 1, consists of 402 amino acids and features one Src homology 3 (SH3) domain and one cysteine-rich domain (CRD). STAC protein is predominantly expressed in the brain, where STAC localizes to the cytoplasm, highlighting STAC′s role as a neuron-specific protein. The presence of SH3 and CRD domains suggests STAC′s involvement in critical signal transduction pathways within neurons, which are essential for proper neuronal function and communication. STAC protein has been implicated in protecting cells from apoptosis, making STAC a potential player in neuroprotection. Given STAC′s specific expression in neurons and involvement in signaling processes, STAC may be linked to various hereditary neurological disorders, underscoring STAC′s importance in both basic neuroscience research and potential therapeutic applications.

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STAC Antibody (J-19) References:

1. Assignment of STAC to human chromosome band 3p22.3 between D3S3718 and D3S1611.  |  Petek, E., et al. 1999. Cytogenet Cell Genet. 84: 184-5. PMID: 10393425
2. Transcriptional networks and cellular senescence in human mammary fibroblasts.  |  Hardy, K., et al. 2005. Mol Biol Cell. 16: 943-53. PMID: 15574883
3. Rapid identification of 14-3-3-binding proteins by protein microarray analysis.  |  Satoh, J., et al. 2006. J Neurosci Methods. 152: 278-88. PMID: 16260042
4. Gene expression pattern in oral cancer cervical lymph node metastasis.  |  Kato, Y., et al. 2006. Oncol Rep. 16: 1009-14. PMID: 17016585
5. Stac, a novel neuron-specific protein with cysteine-rich and SH3 domains.  |  Suzuki, H., et al. 1996. Biochem Biophys Res Commun. 229: 902-9. PMID: 8954993
6. Human and mouse chromosomal mapping of Stac, a neuron-specific protein with an SH3 domain.  |  Kawai, J., et al. 1998. Genomics. 47: 140-2. PMID: 9465308

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-STAC Antibody (J-19) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-STAC Antibody (J-19) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

STAC Antibody (J-19) Specifications

Alternate Product Name: STAC

Product Clone Name: J-19

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 209-318

Epitope Target: STAC

Epitope Species: human

Product Reactivity/Detection: STAC

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for STAC Antibody (J-19): N/A