MDR1/ABCB1 Antibody (G-1): sc-13131

MDR1 Antibody (G-1) is a mouse monoclonal IgG2b kappa light chain antibody designed to detect the human MDR1 protein by targeting the amino acids 1040-1280 epitope. MDR1 mouse monoclonal antibody (G-1) is recommended for applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). The MDR1 protein, also referred to as ABCB1, P-GP, PGY1, ABC20, CD243, GP170, and p-170, plays a crucial role as an ATP-binding cassette (ABC) transporter, functioning as a drug-transport pump that actively effluxes a wide range of chemotherapeutic agents out of cells, thereby contributing to the phenomenon of multiple drug resistance (MDR) observed in cancer treatment. MDR1 is an integral component of the blood-brain barrier, where it protects the brain by transporting potentially harmful substances from the brain back into the bloodstream. Understanding and detecting MDR1 is essential for studying drug resistance mechanisms and developing strategies to overcome therapeutic challenges in various diseases. MDR1 monoclonal antibody (G-1) primarily reacts with the human form of MDR1 and may also cross-react with the mouse homolog Mdr-3, providing additional utility in cross-species studies. Additionally, MDR1 (G-1) antibody is available in multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, allowing for flexible integration into different experimental protocols. MDR1 monoclonal antibody (G-1) is recommended for researchers investigating drug resistance and the protective mechanisms of the blood-brain barrier.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MDR1/ABCB1 Antibody (G-1) has 114 citations in a variety of scientific publications.

Primary antibodies like Anti-MDR1/ABCB1 Antibody (G-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MDR1/ABCB1 Antibody (G-1) Specifications

Alternate Product Name: MDR1

Product Clone Name: G-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1040-1280

Epitope Target: MDR1

Epitope Species: human

Product Reactivity/Detection: MDR1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 114 citations in various scientific publications

Available Conjugates/Forms for MDR1/ABCB1 Antibody (G-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred MDR1/ABCB1 antibody is MDR1/ABCB1 Antibody (D-11): sc-55510.