HSPA8/HSC70 Antibody (1B5): sc-59560
- HSPA8/HSC70 Antibody (1B5) is a rat monoclonal IgG2a, cited in 10 publications, provided at 100 µg/ml
- raised against full length native HSC 70 purified from sodium arsenite treated heat-resistant variants of Chinese hamster cells
- recommended for detection of HSC 70 of mouse, rat, human, Chinese hamster, bovine and canine origin by WB, IP, IF and ELISA
- See HSPA8/HSC70 (B-6): sc-7298 for HSPA8/HSC70 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HSPA8/HSC70 Antibody (1B5). This work is in progress.
HSC 70 Antibody (1B5) is a rat monoclonal IgG2a antibody that detects HSC 70 in mouse, rat, human, Chinese hamster, bovine, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HSC 70, a member of the heat shock protein 70 family, plays a crucial role in cellular stress responses, particularly in the proper folding and assembly of nascent polypeptide chains, which is vital for maintaining protein homeostasis within the cell. HSC 70 is predominantly located in the cytosol and nucleus, where anti-HSC 70 antibody (1B5) can detect its molecular chaperone activity, preventing the aggregation of misfolded proteins and facilitating their refolding or degradation. HSC 70′s ability to respond to cellular stressors, such as heat shock, underscores its importance in protecting cells from damage and ensuring their survival under adverse conditions. HSC 70 interacts with various co-chaperones and client proteins, enhancing its functionality in protein quality control and cellular signaling pathways. Anti-HSC 70 antibody (1B5) serves as an essential tool for researchers studying the dynamics of protein folding and the cellular response to stress, providing insights into the mechanisms underlying various diseases associated with protein misfolding and aggregation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HSPA8/HSC70 Antibody (1B5) | sc-59560 | 100 µg/ml | $316.00 |