PPM1D / WIP1

protein phosphatase, Mg2+/Mn2+ dependent, 1D

PPM1D / WIP1 is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.

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Products

Antibodies (27)

Proteins (5)

ELISA Kits (1)

Type

Over-Expression Lysate (2)

Primary (27)

Recombinant (3)

Sandwich (1)

Target

PPM1D / WIP1 (33)

Reactivity

Human (28)

Mouse (2)

Rat (1)

Application

IHC (3)

IHC-P (2)

WB (25)

ELISA (16)

ICC (1)

IF (1)

Host

rabbit (19)

mouse (8)

Isotype

IgG (17)

IgG1 (7)

IgG1,k (1)

Clonality

monoclonal mc (8)

polyclonal pc (19)

Clone

4D1 (1)

OTI3A7 (2)

OTI3E1 (2)

OTI4H3 (2)

Format

96-Well Strip Plate (1)

APC Conjugated (2)

Azide-free (2)

Biotin Conjugated (2)

Carrier-free (3)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (2)

Unconjugated (17)

Epitope

aa183-212 (7)

aa571-602 (7)

aa1-375 (6)

Publications

No (32)

Yes (1)

Sample Type

Cell Lysates (1)

Tissue Homogenates (1)

Tag

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

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PPM1D / WIP1 Antibody (aa183-212) LS-C162071

Antibody:

PPM1D / WIP1 Rabbit anti-Human Polyclonal (aa183-212) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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Human PPM1D / WIP1 Protein (Recombinant GST, N-terminus) (Full Length) - LS-G31174

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Molecular Weight:

93.1 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PPM1D / WIP1 Protein (Recombinant His) (aa98-375) - LS-G3204

Source:

E. coli

Tag:

His

Price:

50 µg/$361; 250 µg/$739; 10 µg/$261

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PPM1D / WIP1 Antibody (aa1-375, clone OTI4H3) LS-C795826

Antibody:

PPM1D / WIP1 Mouse anti-Human Monoclonal (aa1-375) (OTI4H3) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

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PPM1D / WIP1 Antibody LS-C334560

Antibody:

PPM1D / WIP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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PPM1D / WIP1 Antibody (aa571-602) LS-C101018

(4.0) Rating

(1) Publication(s)

Antibody:

PPM1D / WIP1 Rabbit anti-Human Polyclonal (aa571-602) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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Human PPM1D / WIP1 (Sandwich ELISA) ELISA Kit - LS-F55043

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$730

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PPM1D / WIP1 Antibody LS-C817023

Antibody:

PPM1D / WIP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF

Format:

Unconjugated

Price:

100 µl/$302

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PPM1D / WIP1 Antibody (aa1-375, clone OTI3A7, Carrier-free) LS-C792684

Antibody:

PPM1D / WIP1 Mouse anti-Human Monoclonal (aa1-375) (Carrier-free) (OTI3A7) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

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PPM1D / WIP1 Antibody LS-C676294

Antibody:

PPM1D / WIP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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PPM1D / WIP1 Antibody LS-C676293

Antibody:

PPM1D / WIP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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Human PPM1D / WIP1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68278

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

66.5 kDa

Price:

20 µg/$1,107

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PPM1D / WIP1 Antibody LS-C831748

Antibody:

PPM1D / WIP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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PPM1D / WIP1 Antibody (clone 4D1) LS-C198576

Antibody:

PPM1D / WIP1 Mouse anti-Human Monoclonal (4D1) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$335

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PPM1D / WIP1 Antibody (aa183-212) LS-C324225

Antibody:

PPM1D / WIP1 Rabbit anti-Human Polyclonal (aa183-212) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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PPM1D / WIP1 Antibody (aa183-212, Biotin) LS-C216917

Antibody:

PPM1D / WIP1 Rabbit anti-Human Polyclonal (aa183-212) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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PPM1D / WIP1 Antibody (aa183-212, FITC) LS-C216918

Antibody:

PPM1D / WIP1 Rabbit anti-Human Polyclonal (aa183-212) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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PPM1D / WIP1 Antibody (aa183-212, APC) LS-C216916

Antibody:

PPM1D / WIP1 Rabbit anti-Human Polyclonal (aa183-212) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

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PPM1D / WIP1 Antibody (aa183-212, PE) LS-C216919

Antibody:

PPM1D / WIP1 Rabbit anti-Human Polyclonal (aa183-212) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

PPM1D / WIP1 Antibody (aa183-212, Azide-free, HRP) LS-C216920

Antibody:

PPM1D / WIP1 Rabbit anti-Human Polyclonal (aa183-212) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

PPM1D / WIP1 Antibody (aa571-602) LS-C328370

Antibody:

PPM1D / WIP1 Rabbit anti-Human Polyclonal (aa571-602) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

PPM1D / WIP1 Antibody (aa571-602, Biotin) LS-C220465

Antibody:

PPM1D / WIP1 Rabbit anti-Human Polyclonal (aa571-602) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

PPM1D / WIP1 Antibody (aa571-602, FITC) LS-C220466

Antibody:

PPM1D / WIP1 Rabbit anti-Human Polyclonal (aa571-602) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

PPM1D / WIP1 Antibody (aa571-602, APC) LS-C220464

Antibody:

PPM1D / WIP1 Rabbit anti-Human Polyclonal (aa571-602) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC

• Unconjugated
• Biotin
• FITC
• More...
  • APC

Select

PPM1D / WIP1 Antibody (aa1-375, clone OTI3E1) LS-C795839

Antibody:

PPM1D / WIP1 Mouse anti-Human Monoclonal (aa1-375) (OTI3E1) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

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