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PARP4 / VPARP encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.
Gene Name: | poly (ADP-ribose) polymerase family, member 4 |
Synonyms: | PARP4, 193 kDa vault protein, ADPRTL1, H5 proline-rich, I-alpha-I-related, PARPL, PH5P, Poly(ADP-ribose) synthetase, Poly [ADP-ribose] polymerase 4, VPARP, VWA5C, p193, Vault protein, 193-kDa, ARTD4, VAULT3, KIAA0177, PARP-4, PARP-related |
Target Sequences: | NM_006437 NP_006428.2 Q9UKK3 |
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