Ret Antibody (8D10C9): sc-101422

Ret Antibody (8D10C9) is a mouse monoclonal IgG1 antibody that detects Ret in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Ret is a crucial proto-oncogene that encodes a receptor tyrosine kinase involved in the signaling pathways of glial cell line-derived neurotrophic factor (GDNF), which plays a significant role in the development and maintenance of the nervous system. Ret (8D10C9) antibody recognizes the protein primarily located on the cell membrane, where Ret functions as a receptor that, upon binding to its ligand, activates downstream signaling cascades essential for neuronal survival and differentiation. This localization enables Ret to mediate critical cellular responses to external signals, influencing processes such as cell growth and survival. Notably, aberrations in the Ret gene, including tumor-specific rearrangements, have been implicated in various cancers, particularly papillary thyroid carcinoma, where these changes lead to the production of constitutively active fusion proteins that disrupt normal signaling pathways. Anti-Ret antibody (8D10C9) serves as an invaluable tool for researchers studying Ret in both normal physiology and disease states, providing insights into Ret function and potential as a therapeutic target.

The preferred Ret antibody is Ret Antibody (C-3): sc-365943.