ErbB2/HER2 Antibody (C-12): sc-374382
- ErbB2/HER2 Antibody (C-12) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 983-1017 within a cytoplasmic domain of Neu of human origin
- recommended for detection of Neu of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine and porcine
- See ErbB2/HER2 (3B5): sc-33684 for ErbB2/HER2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ErbB2/HER2 Antibody (C-12). This work is in progress.
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SEE ALSO...
Neu Antibody (C-12) is a mouse monoclonal IgM antibody that detects Neu in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Neu, also known as ErbB-2 or HER2, is a member of the epidermal growth factor receptor family and plays a critical role in cell signaling pathways that regulate cell growth, survival, and differentiation. Anti-Neu antibody (C-12) targets a protein primarily located on the cell membrane, where Neu functions as a receptor tyrosine kinase, facilitating communication between cells and their environment. This localization allows Neu to respond to extracellular signals, leading to the activation of downstream signaling cascades that can promote tumorigenesis when dysregulated. Notably, Neu is often overexpressed in various carcinomas, particularly in 20-30% of breast cancers, making Neu a significant biomarker for disease prognosis and a potential target for therapeutic interventions. Neu (C-12) antibody serves as an essential tool for researchers investigating the role of Neu in cancer biology and therapeutic development, providing insights into its function and interactions within the cellular context.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ErbB2/HER2 Antibody (C-12) | sc-374382 | 200 µg/ml | $316.00 | |||
ErbB2/HER2 (C-12) Neutralizing Peptide | sc-374382 P | 100 µg/0.5 ml | $68.00 |