ErbB4/HER4 Antibody (A-5): sc-514327
- ErbB4/HER4 Antibody (A-5) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1176-1198 within a C-terminal cytoplasmic domain of ErbB-4 of human origin
- recommended for detection of ErbB-4 of mouse, rat and human origin by WB, IP, IF and ELISA
- See ErbB4/HER4 (C-7): sc-8050 for ErbB4/HER4 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ErbB4/HER4 Antibody (A-5). This work is in progress.
ErbB-4 Antibody (A-5) is a mouse monoclonal IgM antibody that detects ErbB-4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ErbB-4 is a member of the epidermal growth factor receptor family, which plays a crucial role in cell signaling pathways that regulate cell proliferation and differentiation. ErbB-4 is primarily located on the cell membrane, where ErbB-4 can form homodimers or heterodimers upon ligand binding, a process essential for activation and subsequent signaling. ErbB-4′s membrane localization enables interaction with various ligands, such as heregulin, which promotes proteolytic cleavage, resulting in ectodomain release and activation of downstream signaling cascades. These pathways are vital for normal cellular functions and are often dysregulated in various cancers, particularly breast carcinoma, where ErbB-4 expression is notably high. Anti-ErbB-4 antibody (A-5) is an invaluable tool for researchers studying this receptor in cancer biology and therapeutic interventions.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ErbB4/HER4 Antibody (A-5) | sc-514327 | 200 µg/ml | $316.00 | |||
ErbB4/HER4 (A-5) Neutralizing Peptide | sc-514327 P | 100 µg/0.5 ml | $68.00 |