Jagged1 Antibody (E-12): sc-390177

Jagged1 Antibody (E-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects Jagged1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-Jagged1 antibody (E-12) is available in both non-conjugated and various conjugated forms, including agarose, phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Jagged1 plays a crucial role in the Notch signaling pathway, which is essential for various developmental processes, including cell fate determination and tissue differentiation. Specifically, Jagged1 acts as a ligand for Notch receptors, facilitating communication between adjacent cells and influencing developmental pathways. This interaction is particularly important in cardiovascular development and hematopoiesis, where Jagged1 helps regulate the balance between cell proliferation and differentiation. Notably, aberrations in Jagged1 expression have been linked to several pathologies, including cervical squamous cell carcinoma and congenital heart defects such as Familial Tetralogy of Fallot, underscoring Jagged1′s significance in both normal physiology and disease states.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Jagged1 Antibody (E-12) References:

1. Fifteen novel mutations in the JAGGED1 gene of patients with Alagille syndrome.  |  Crosnier, C., et al. 2001. Hum Mutat. 17: 72-3. PMID: 11139247
2. Familial Tetralogy of Fallot caused by mutation in the jagged1 gene.  |  Eldadah, ZA., et al. 2001. Hum Mol Genet. 10: 163-9. PMID: 11152664
3. Hypoxia-induced lncHILAR promotes renal cancer metastasis via ceRNA for the miR-613/206/ 1-1-3p/Jagged-1/Notch/CXCR4 signaling pathway.  |  Hu, G., et al. 2021. Mol Ther. 29: 2979-2994. PMID: 34058384
4. Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis.  |  Yu, J., et al. 2021. Sci Transl Med. 13: PMID: 34162749
5. Nidogen-2 Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells and Prevents Neointima Formation via Bridging Jagged1-Notch3 Signaling.  |  Mao, C., et al. 2021. Circulation. 144: 1244-1261. PMID: 34315224
6. Jagged-1 Reduces Th2 Inflammation and Memory Cell Expansion in Allergic Airway Disease.  |  Kimura, S., et al. 2023. Immunohorizons. 7: 168-176. PMID: 36729482
7. Defective jagged-1 signaling affects GnRH development and contributes to congenital hypogonadotropic hypogonadism.  |  Cotellessa, L., et al. 2023. JCI Insight. 8: PMID: 36729644
8. Adipose-Derived Mesenchymal Stem Cell Facilitate Hematopoietic Stem Cell Proliferation via the Jagged-1/Notch-1/Hes Signaling Pathway.  |  Wang, H., et al. 2023. Stem Cells Int. 2023: 1068405. PMID: 38020206
9. Jagged: a mammalian ligand that activates Notch1.  |  Lindsell, CE., et al. 1995. Cell. 80: 909-17. PMID: 7697721
10. dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line.  |  Laborda, J., et al. 1993. J Biol Chem. 268: 3817-20. PMID: 8095043
11. JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions.  |  Valsecchi, C., et al. 1997. Mech Dev. 69: 203-7. PMID: 9486542

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Jagged1 Antibody (E-12) has 45 citations in a variety of scientific publications.

Primary antibodies like Anti-Jagged1 Antibody (E-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Jagged1 Antibody (E-12) Specifications

Alternate Product Name: Jagged1

Product Clone Name: E-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1110-1218

Epitope Target: Jagged1

Epitope Species: human

Product Reactivity/Detection: Jagged1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 45 citations in various scientific publications

Available Conjugates/Forms for Jagged1 Antibody (E-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, PE: Phycoerythrin