IFN-α Antibody (E-7): sc-373756
- IFN-α Antibody (E-7) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against full length recombinant IFN-α1/13 of human origin
- recommended for detection of IFN-α1 and IFN-α13 of human origin by WB, IP, IF and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for IFN-α Antibody (E-7) for WB applications. This reagent is now offered in a bundle with IFN-α Antibody (E-7) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
IFN-α Antibody (E-7) is a mouse monoclonal IgG2a antibody that detects interferon-alpha (IFN-α) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IFN-α plays a crucial role in the immune response, primarily functioning as a cytokine that mediates antiviral activity and modulates the immune system. Anti-IFN-α antibody (E-7) enables detection of genes involved in the antiviral response for controlling viral infections and enhancing immune cell activity. IFN-α exhibits antitumor properties, making IFN-α an important therapeutic agent in treating certain malignancies and autoimmune diseases. IFN-α is secreted by virus-infected cells and acts on neighboring cells to establish an antiviral state, thereby limiting viral replication and spread. IFN-α interaction with type I interferon receptor (IFN-αR), a multisubunit complex, initiates signaling pathways leading to immune response activation. With diverse functions and clinical significance, IFN-α remains a key focus in immunology and therapeutic research, making IFN-α monoclonal antibody (E-7) an invaluable tool for studying various biological processes.
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IFN-α Antibody (E-7) References:
- IFN-alpha and IFN-beta: a link between immune memory and chronic inflammation. | Akbar, AN., et al. 2000. Immunol Today. 21: 337-42. PMID: 10871875
- The immunomodulatory role of IFN-alpha or maltose-stabilized IFN-alpha on T-cell activation. | Kohno, K., et al. 1992. Lymphokine Cytokine Res. 11: 221-7. PMID: 1420600
- IFN-alpha regulates TLR-dependent gene expression of IFN-alpha, IFN-beta, IL-28, and IL-29. | Sirén, J., et al. 2005. J Immunol. 174: 1932-7. PMID: 15699120
- IFN-alpha and novel strategies of combination therapy for cancer. | Bracci, L., et al. 2007. Ann N Y Acad Sci. 1112: 256-68. PMID: 17567945
- IFN-α as a vaccine adjuvant: recent insights into the mechanisms and perspectives for its clinical use. | Rizza, P., et al. 2011. Expert Rev Vaccines. 10: 487-98. PMID: 21506646
- Viral Infection or IFN-α Alters Mitotic Spindle Orientation by Modulating Pericentrin Levels. | McDougall, WM., et al. 2019. iScience. 12: 270-279. PMID: 30716700
- Role of STAT1 in the resistance of HBV to IFN-α. | Xu, B., et al. 2021. Exp Ther Med. 21: 550. PMID: 33850522
- STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK-STAT endosomal activation. | Zanin, N., et al. 2023. Nat Cell Biol. 25: 425-438. PMID: 36797476
- A common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity. | Al Qureshah, F., et al. 2025. J Exp Med. 222: PMID: 39680367
- Structure and expression of human IFN-alpha genes. | Weissmann, C., et al. 1982. Philos Trans R Soc Lond B Biol Sci. 299: 7-28. PMID: 6128751
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IFN-α Antibody (E-7) | sc-373756 | 200 µg/ml | $316.00 | |||
IFN-α Antibody (E-7): m-IgGκ BP-HRP Bundle | sc-535307 | 200 µg Ab; 40 µg BP | $354.00 |