pyridoxal phosphatase Antibody (F-2): sc-271379
- pyridoxal phosphatase Antibody (F-2) is a mouse monoclonal IgG1 λ pyridoxal phosphatase antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 254-286 at the C-terminus of pyridoxal phosphatase of human origin
- pyridoxal phosphatase Antibody (F-2) is recommended for detection of pyridoxal phosphatase of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine and bovine
- Anti-pyridoxal phosphatase Antibody (F-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of pyridoxal phosphatase (F-2): sc-271379.
- m-IgGλ BP-HRP (mouse IgGλ binding protein-HRP) is the preferred secondary detection reagent for pyridoxal phosphatase Antibody (F-2) for WB applications. This reagent is now offered in a bundle with pyridoxal phosphatase Antibody (F-2) (see ordering information below). For additional m-IgGλ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Pyridoxal phosphatase Antibody (F-2) is a mouse monoclonal IgG1 antibody that detects pyridoxal phosphatase of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-pyridoxal phosphatase antibody (F-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Pyridoxal phosphatase (PLPase) is a crucial enzyme composed of 296 amino acids that plays a vital role in vitamin B6 metabolism by catalyzing the dephosphorylation of pyridoxal 5′-phosphate, the active form of this essential vitamin. PLPase is predominantly expressed in the central nervous system, particularly in the brain, where PLPase is involved in the synthesis of neurotransmitters, including serotonin and gamma-aminobutyric acid, which are critical for maintaining proper neuronal function and communication. Dysregulation of PLPase activity has been linked to various neurological disorders and certain types of cancer, as autoantibodies against PLPase have shown a strong correlation with these conditions. Anti-pyridoxal phosphatase antibody (F-2) in multiple formats enhances research and diagnostic applications, making PLPase studies in health and disease more accessible and comprehensive.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
pyridoxal phosphatase Antibody (F-2) References:
- Human pyridoxal phosphatase. Molecular cloning, functional expression, and tissue distribution. | Jang, YM., et al. 2003. J Biol Chem. 278: 50040-6. PMID: 14522954
- Cytosolic NADP phosphatases I and II from Arthrobacter sp. strain KM: implication in regulation of NAD+/NADP+ balance. | Kawai, S., et al. 2004. J Basic Microbiol. 44: 185-96. PMID: 15162392
- Genomic organization, tissue distribution and deletion mutation of human pyridoxine 5'-phosphate oxidase. | Kang, JH., et al. 2004. Eur J Biochem. 271: 2452-61. PMID: 15182361
- B-6 vitamers and 4-pyridoxic acid in the plasma, erythrocytes, and urine of postmenopausal women. | Massé, PG., et al. 2004. Am J Clin Nutr. 80: 946-51. PMID: 15447904
- Pyridoxal phosphatase is a novel cancer autoantigen in the central nervous system. | Bøe, AS., et al. 2004. Br J Cancer. 91: 1508-14. PMID: 15452547
- Inactivation of brain myo-inositol monophosphate phosphatase by pyridoxal-5'-phosphate. | Kim, DW., et al. 2005. J Biochem Mol Biol. 38: 58-64. PMID: 15715947
- YZGD from Paenibacillus thiaminolyticus, a pyridoxal phosphatase of the HAD (haloacid dehalogenase) superfamily and a versatile member of the Nudix (nucleoside diphosphate x) hydrolase superfamily. | Tirrell, IM., et al. 2006. Biochem J. 394: 665-74. PMID: 16336194
- Brain pyridoxine-5-phosphate oxidase. Modulation of its catalytic activity by reaction with pyridoxal 5-phosphate and analogs. | Choi, SY., et al. 1987. J Biol Chem. 262: 12013-7. PMID: 3114257
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
pyridoxal phosphatase Antibody (F-2) | sc-271379 | 200 µg/ml | $316.00 | |||
pyridoxal phosphatase Antibody (F-2): m-IgGλ BP-HRP Bundle | sc-521923 | 200 µg Ab, 40 µg BP | $354.00 | |||
pyridoxal phosphatase Antibody (F-2) AC | sc-271379 AC | 500 µg/ml, 25% agarose | $416.00 | |||
pyridoxal phosphatase Antibody (F-2) HRP | sc-271379 HRP | 200 µg/ml | $316.00 | |||
pyridoxal phosphatase Antibody (F-2) FITC | sc-271379 FITC | 200 µg/ml | $330.00 | |||
pyridoxal phosphatase Antibody (F-2) PE | sc-271379 PE | 200 µg/ml | $343.00 | |||
pyridoxal phosphatase Antibody (F-2) Alexa Fluor® 488 | sc-271379 AF488 | 200 µg/ml | $357.00 | |||
pyridoxal phosphatase Antibody (F-2) Alexa Fluor® 546 | sc-271379 AF546 | 200 µg/ml | $357.00 | |||
pyridoxal phosphatase Antibody (F-2) Alexa Fluor® 594 | sc-271379 AF594 | 200 µg/ml | $357.00 | |||
pyridoxal phosphatase Antibody (F-2) Alexa Fluor® 647 | sc-271379 AF647 | 200 µg/ml | $357.00 | |||
pyridoxal phosphatase Antibody (F-2) Alexa Fluor® 680 | sc-271379 AF680 | 200 µg/ml | $357.00 | |||
pyridoxal phosphatase Antibody (F-2) Alexa Fluor® 790 | sc-271379 AF790 | 200 µg/ml | $357.00 | |||
pyridoxal phosphatase (F-2) Neutralizing Peptide | sc-271379 P | 100 µg/0.5 ml | $68.00 |