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PP1α Antibody (G-4) is a mouse monoclonal IgG2b kappa light chain antibody designed to detect the full-length human phosphatase PP1α protein, also known as PPP1CA or Protein Phosphatase 1α. PP1α monoclonal antibody (G-4) is reactive across multiple species, including mouse, rat, human, canine, bovine, and porcine, making it versatile for various applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Available in both non-conjugated form and with conjugations like agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® variants, anti-PP1α antibody (G-4) offers flexibility for diverse experimental needs. Phosphatase PP1α is a critical serine/threonine-protein phosphatase localized predominantly in both the nucleus and cytoplasm of eukaryotic cells, where PP1α plays an essential role in regulating various cellular functions including cell division, homeostasis, and apoptosis through the dephosphorylation of target proteins. The precise localization of PP1α within the cell is vital for function, as PP1α ensures the correct modulation of phosphorylation states in specific cellular compartments, thereby maintaining cellular balance and responding to signaling cues. PP1α operates as part of the PP1 holoenzyme complex, interacting with regulatory and variable subunits to achieve substrate specificity and regulation. PP1α activity is tightly controlled by inhibitory proteins such as NIPP-1, and regulation through phosphorylation by kinases like cAMP-PK and casein kinase II is crucial for activating or inhibiting phosphatase activity as needed. Understanding and detecting PP1α localization and activity with PP1α (G-4) antibody is therefore fundamental for studies investigating cellular signaling pathways, protein interactions, and the mechanisms underlying various physiological and pathological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PP1α Antibody (G-4) | sc-271762 | 200 µg/ml | $316.00 | |||
PP1α Antibody (G-4) AC | sc-271762 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PP1α Antibody (G-4) HRP | sc-271762 HRP | 200 µg/ml | $316.00 | |||
PP1α Antibody (G-4) FITC | sc-271762 FITC | 200 µg/ml | $330.00 | |||
PP1α Antibody (G-4) PE | sc-271762 PE | 200 µg/ml | $343.00 | |||
PP1α Antibody (G-4) Alexa Fluor® 488 | sc-271762 AF488 | 200 µg/ml | $357.00 | |||
PP1α Antibody (G-4) Alexa Fluor® 546 | sc-271762 AF546 | 200 µg/ml | $357.00 | |||
PP1α Antibody (G-4) Alexa Fluor® 594 | sc-271762 AF594 | 200 µg/ml | $357.00 | |||
PP1α Antibody (G-4) Alexa Fluor® 647 | sc-271762 AF647 | 200 µg/ml | $357.00 | |||
PP1α Antibody (G-4) Alexa Fluor® 680 | sc-271762 AF680 | 200 µg/ml | $357.00 | |||
PP1α Antibody (G-4) Alexa Fluor® 790 | sc-271762 AF790 | 200 µg/ml | $357.00 | |||
PP1α (G-4) Neutralizing Peptide | sc-271762 P | 100 µg/0.5 ml | $68.00 |