MEK-2 Antibody (8E8): sc-81473
- MEK-2 Antibody (8E8) is a mouse monoclonal IgG1, cited in 2 publications, provided at 50 µg/0.5 ml
- raised against N-terminus of MEK-2 of human origin
- recommended for detection of MEK-2 of mouse, rat, human and canine origin by WB and IP
- See MEK-2 (A-1): sc-13159 for MEK-2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MEK-2 Antibody (8E8). This work is in progress.
MEK-2 Antibody (8E8) is a mouse monoclonal IgG1 antibody designed to target the N-terminus of human MEK-2, also known as MAP2K2 or MKK2. MEK-2 is a crucial dual-specificity protein kinase located primarily in the cytoplasm, where it plays an essential role in the MAPK/ERK signaling pathway by phosphorylating and activating ERK1/2. This cytoplasmic localization is vital for interaction with upstream activators and downstream effectors, ensuring precise regulation of cellular processes such as proliferation, differentiation, and survival. The strategic placement of MEK-2 within the cell underscores its importance in maintaining cellular homeostasis and responding to extracellular signals. MEK-2 (8E8) monoclonal antibody exhibits broad species reactivity, effectively recognizing MEK-2 from mouse, rat, human, and canine origins, making it an invaluable tool for western blotting (WB) and immunoprecipitation (IP) applications across various model organisms. By targeting a conserved epitope, MEK-2 (8E8) antibody facilitates comparative studies and cross-species analyses, enhancing research versatility and applicability. Additionally, understanding the role and localization of MEK-2 is particularly significant in cancer research, where the MAPK/ERK pathway is frequently dysregulated. MEK-2 (8E8) monoclonal antibody ensures reliable and consistent detection of MEK-2, enabling accurate quantification and analysis in experimental setups.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MEK-2 Antibody (8E8) | sc-81473 | 50 µg/0.5 ml | $316.00 |