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PTBP-2 Antibody (A-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects PTBP-2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PTBP-2 (A-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PTBP-2, also known as polypyrimidine tract binding protein 2 or neural polypyrimidine tract-binding protein, is a crucial RNA-binding protein predominantly expressed in brain, with additional presence in heart and skeletal muscle tissues. PTBP-2 is localized in the nucleus and features four RNA recognition motif domains, which are essential for regulating exon splicing and stabilizing mRNAs in the cytoplasm. PTBP-2 exists in six isoforms due to alternative splicing, with isoforms 1 and 2 being specific to neuronal tissues, while isoforms 3 through 6 are found in non-neuronal tissues. The diversity of these isoforms allows for modulation of RNA-binding properties, which can influence gene expression and cellular responses, making PTBP-2 a vital player in post-transcriptional regulation and a potential target for therapeutic interventions in neurological disorders.
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Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PTBP-2 Antibody (A-10) | sc-376316 | 200 µg/ml | $316.00 | |||
PTBP-2 Antibody (A-10): m-IgG Fc BP-HRP Bundle | sc-529851 | 200 µg Ab; 10 µg BP | $354.00 | |||
PTBP-2 Antibody (A-10): m-IgGκ BP-HRP Bundle | sc-522914 | 200 µg Ab, 40 µg BP | $354.00 | |||
PTBP-2 Antibody (A-10) AC | sc-376316 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PTBP-2 Antibody (A-10) HRP | sc-376316 HRP | 200 µg/ml | $316.00 | |||
PTBP-2 Antibody (A-10) FITC | sc-376316 FITC | 200 µg/ml | $330.00 | |||
PTBP-2 Antibody (A-10) PE | sc-376316 PE | 200 µg/ml | $343.00 | |||
PTBP-2 Antibody (A-10) Alexa Fluor® 488 | sc-376316 AF488 | 200 µg/ml | $357.00 | |||
PTBP-2 Antibody (A-10) Alexa Fluor® 546 | sc-376316 AF546 | 200 µg/ml | $357.00 | |||
PTBP-2 Antibody (A-10) Alexa Fluor® 594 | sc-376316 AF594 | 200 µg/ml | $357.00 | |||
PTBP-2 Antibody (A-10) Alexa Fluor® 647 | sc-376316 AF647 | 200 µg/ml | $357.00 | |||
PTBP-2 Antibody (A-10) Alexa Fluor® 680 | sc-376316 AF680 | 200 µg/ml | $357.00 | |||
PTBP-2 Antibody (A-10) Alexa Fluor® 790 | sc-376316 AF790 | 200 µg/ml | $357.00 |