PLRG1 Antibody (E-12): sc-376171
- PLRG1 Antibody (E-12) is a mouse monoclonal IgG2a κ PLRG1 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 127-165 within an internal region of PLRG1 of human origin
- PLRG1 Antibody (E-12) is recommended for detection of PLRG1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-PLRG1 Antibody (E-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of PLRG1 (E-12): sc-376171.
- m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PLRG1 Antibody (E-12) for WB applications. These reagents are now offered in bundles with PLRG1 Antibody (E-12) (see ordering information below).
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PLRG1 Antibody (E-12) is a mouse monoclonal IgG2a kappa light chain antibody that detects PLRG1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PLRG1 (E-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PLRG1, also known as pleiotropic regulator 1 or PRL1, is a 514 amino acid protein primarily localized to nuclear speckles and contains seven WD repeats. These WD repeats facilitate the formation of a tertiary propeller structure essential for PLRG1′s role in the multiprotein Cdc5L complex. This complex is vital for spliceosome assembly and pre-mRNA splicing process, which regulates gene expression. PLRG1 plays a significant role in chromatin assembly, cell cycle control, signal transduction, and RNA processing, making PLRG1 an important target for research in gene regulation and cellular function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PLRG1 Antibody (E-12) References:
- The WD repeat: a common architecture for diverse functions. | Smith, TF., et al. 1999. Trends Biochem Sci. 24: 181-5. PMID: 10322433
- Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. | Ajuh, P., et al. 2000. EMBO J. 19: 6569-81. PMID: 11101529
- A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing. | Ajuh, P., et al. 2001. J Biol Chem. 276: 42370-81. PMID: 11544257
- Large-scale proteomic analysis of the human spliceosome. | Rappsilber, J., et al. 2002. Genome Res. 12: 1231-45. PMID: 12176931
- Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1. | Ajuh, P. and Lamond, AI. 2003. Nucleic Acids Res. 31: 6104-16. PMID: 14576297
- Nucleolar proteome dynamics. | Andersen, JS., et al. 2005. Nature. 433: 77-83. PMID: 15635413
- The ancient regulatory-protein family of WD-repeat proteins. | Neer, EJ., et al. 1994. Nature. 371: 297-300. PMID: 8090199
- Pleiotropic control of glucose and hormone responses by PRL1, a nuclear WD protein, in Arabidopsis. | Németh, K., et al. 1998. Genes Dev. 12: 3059-73. PMID: 9765207
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PLRG1 Antibody (E-12) | sc-376171 | 200 µg/ml | $316.00 | |||
PLRG1 Antibody (E-12): m-IgGκ BP-HRP Bundle | sc-522860 | 200 µg Ab, 40 µg BP | $354.00 | |||
PLRG1 Antibody (E-12): m-IgG2a BP-HRP Bundle | sc-546122 | 200 µg Ab; 10 µg BP | $354.00 | |||
PLRG1 Antibody (E-12) AC | sc-376171 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PLRG1 Antibody (E-12) HRP | sc-376171 HRP | 200 µg/ml | $316.00 | |||
PLRG1 Antibody (E-12) FITC | sc-376171 FITC | 200 µg/ml | $330.00 | |||
PLRG1 Antibody (E-12) PE | sc-376171 PE | 200 µg/ml | $343.00 | |||
PLRG1 Antibody (E-12) Alexa Fluor® 488 | sc-376171 AF488 | 200 µg/ml | $357.00 | |||
PLRG1 Antibody (E-12) Alexa Fluor® 546 | sc-376171 AF546 | 200 µg/ml | $357.00 | |||
PLRG1 Antibody (E-12) Alexa Fluor® 594 | sc-376171 AF594 | 200 µg/ml | $357.00 | |||
PLRG1 Antibody (E-12) Alexa Fluor® 647 | sc-376171 AF647 | 200 µg/ml | $357.00 | |||
PLRG1 Antibody (E-12) Alexa Fluor® 680 | sc-376171 AF680 | 200 µg/ml | $357.00 | |||
PLRG1 Antibody (E-12) Alexa Fluor® 790 | sc-376171 AF790 | 200 µg/ml | $357.00 | |||
PLRG1 (E-12) Neutralizing Peptide | sc-376171 P | 100 µg/0.5 ml | $68.00 |