HP1γ Antibody (E-7): sc-365085
- HP1γ Antibody (E-7) is a mouse monoclonal IgG2b κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 6-25 at the N-terminus of HP1γ of human origin
- recommended for detection of HP1γ of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for HP1γ Antibody (E-7) for WB applications. These reagents are now offered in bundles with HP1γ Antibody (E-7) (see ordering information below).
HP1γ Antibody (E-7) is a mouse monoclonal IgG2b light chain antibody that detects HP1γ in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HP1γ, a member of the heterochromatin protein family, plays a crucial role in the regulation of gene expression and the maintenance of chromatin structure. HP1γ is primarily located in the nucleus, where HP1γ binds to heterochromatin and is essential for the formation and stability of this tightly packed chromatin. HP1γ presence in heterochromatin is vital for the repression of transcription and the protection of genomic integrity, as HP1γ helps to prevent unwanted recombination and transcriptional activity in these regions. Additionally, HP1γ interacts with various proteins, including chromatin remodeling complexes and histone methyltransferases, which further underscores HP1γ importance in chromatin dynamics and epigenetic regulation. Anti-HP1γ antibody (E-7) is an invaluable tool for researchers studying chromatin biology, gene regulation, and the molecular mechanisms underlying various diseases associated with chromatin dysregulation.
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HP1γ Antibody (E-7) References:
- HP-1γ Controls High-Affinity Antibody Response to T-Dependent Antigens. | Ha, N., et al. 2014. Front Immunol. 5: 271. PMID: 24971082
- Cbx3/HP1γ deficiency confers enhanced tumor-killing capacity on CD8+ T cells. | Sun, M., et al. 2017. Sci Rep. 7: 42888. PMID: 28220815
- A regulatory circuit HP1γ/miR-451a/c-Myc promotes prostate cancer progression. | Chang, C., et al. 2018. Oncogene. 37: 415-426. PMID: 28967902
- HPV-mediated nuclear export of HP1γ drives cervical tumorigenesis by downregulation of p53. | Yi, SA., et al. 2020. Cell Death Differ. 27: 2537-2551. PMID: 32203172
- HP1γ regulates H3K36 methylation and pluripotency in embryonic stem cells. | Zaidan, NZ. and Sridharan, R. 2020. Nucleic Acids Res. 48: 12660-12674. PMID: 33237287
- HP1γ binding pre-mRNA intronic repeats modulates RNA splicing decisions. | Rachez, C., et al. 2021. EMBO Rep. 22: e52320. PMID: 34312949
- Targeting Cbx3/HP1γ Induces LEF-1 and IL-21R to Promote Tumor-Infiltrating CD8 T-Cell Persistence. | Le, PT., et al. 2021. Front Immunol. 12: 738958. PMID: 34721405
- Deacetylation induced nuclear condensation of HP1γ promotes multiple myeloma drug resistance. | Li, X., et al. 2023. Nat Commun. 14: 1290. PMID: 36894562
- HP1γ Prevents Activation of the cGAS/STING Pathway by Preserving Nuclear Envelope and Genomic Integrity in Colon Adenocarcinoma Cells. | Mata-Garrido, J., et al. 2023. Int J Mol Sci. 24: PMID: 37108510
- CGRP causes anxiety via HP1γ-KLF11-MAOB pathway and dopamine in the dorsal hippocampus. | Hashikawa-Hobara, N., et al. 2024. Commun Biol. 7: 322. PMID: 38503899
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HP1γ Antibody (E-7) | sc-365085 | 200 µg/ml | $316.00 | |||
HP1γ Antibody (E-7): m-IgGκ BP-HRP Bundle | sc-535149 | 200 µg Ab; 40 µg BP | $354.00 | |||
HP1γ Antibody (E-7): m-IgG2b BP-HRP Bundle | sc-549346 | 200 µg Ab; 10 µg BP | $354.00 | |||
HP1γ (E-7) Neutralizing Peptide | sc-365085 P | 100 µg/0.5 ml | $68.00 |