Dicer Antibody (D-11): sc-136980
- Dicer Antibody (D-11) is a mouse monoclonal IgG2a κ, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 1701-1912 mapping at the C-terminus of Dicer of human origin
- recommended for detection of Dicer of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See Dicer (F-10): sc-136979 for Dicer antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Dicer Antibody (D-11) for WB and IHC(P) applications. These reagents are now offered in bundles with Dicer Antibody (D-11) (see ordering information below).
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SEE ALSO...
Dicer Antibody (D-11) is a mouse monoclonal IgG2a antibody that detects Dicer in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Dicer is a crucial component of the RNA interference pathway, playing a vital role in the processing of microRNAs and small interfering RNAs, which are essential for regulating gene expression and maintaining cellular homeostasis. Dicer (D-11) antibody localizes primarily in the cytoplasm of mammalian cells, where Dicer co-localizes with calreticulin in the endoplasmic reticulum, highlighting its importance in the cellular machinery that governs RNA metabolism. This localization allows for efficient processing of RNA substrates, ensuring that small RNA molecules produced can effectively target and degrade homologous mRNAs, thereby influencing various biological processes such as development, differentiation, and response to stress. The gene encoding human Dicer is mapped to chromosome 14q31, and Dicer expression is observed in several tissues, including the brain, heart, liver, lung, pancreas, kidney, and placenta, underscoring its fundamental role in diverse physiological functions. Anti-Dicer antibody (D-11) is an invaluable tool for researchers investigating the intricate mechanisms of RNA interference and its implications in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dicer Antibody (D-11) | sc-136980 | 200 µg/ml | $316.00 | |||
Dicer Antibody (D-11): m-IgG Fc BP-HRP Bundle | sc-539911 | 200 µg Ab; 10 µg BP | $354.00 | |||
Dicer Antibody (D-11): m-IgG2a BP-HRP Bundle | sc-546817 | 200 µg Ab; 10 µg BP | $354.00 |