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ArgRS Antibody (ZB-12): sc-100990

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Datasheets
  • ArgRS Antibody (ZB-12) is a mouse monoclonal IgM ArgRS antibody provided at 200 µl ascites
  • raised against recombinant ArgRS of human origin
  • recommended for detection of ArgRS of human origin by WB, IP and ELISA
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ArgRS Antibody (ZB-12). This work is in progress.

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    ArgRS Antibody (ZB-12) is a mouse monoclonal IgM antibody that detects ArgRS protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-ArgRS antibody (ZB-12) is available as the non-conjugated isotype antibody. Arginyl-tRNA synthetase (ArgRS), also known as RARS or DALRD1, is a crucial enzyme in the protein synthesis process, responsible for the accurate attachment of the amino acid arginine to its corresponding tRNA. This function is vital because it ensures the fidelity of protein translation, which is essential for maintaining cellular function and overall organismal health. ArgRS is primarily located in the cytoplasm, where ArgRS operates as a monomer but can also interact with other tRNA synthetases and auxiliary proteins to form a multisubunit complex, enhancing catalytic efficiency. ArgRS activity is dependent on the presence of ATP, arginine, and tRNA, as ArgRS catalyzes the formation of arginine-tRNA(Arg) at its active site. Notably, two cytoplasmic forms of ArgRS have been identified in mammals, distinguished by a 73 amino acid sequence that is critical for the assembly of the multisubunit complex, highlighting ArgRS structural diversity and regulatory mechanisms in cellular processes.

    For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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    ArgRS Antibody (ZB-12) References:

    1. Macromolecular assemblage of aminoacyl-tRNA synthetases: quantitative analysis of protein-protein interactions and mechanism of complex assembly.  |  Robinson, JC., et al. 2000. J Mol Biol. 304: 983-94. PMID: 11124041
    2. Arginyl-tRNA synthetase with signature sequence KMSK from Bacillus stearothermophilus.  |  Li, J., et al. 2003. Biochem J. 376: 773-9. PMID: 13678419
    3. Escherichia coli tRNA(4)(Arg)(UCU) induces a constrained conformation of the crucial Omega-loop of arginyl-tRNA synthetase.  |  Yao, YN., et al. 2004. Biochem Biophys Res Commun. 313: 129-34. PMID: 14672708
    4. The tRNA-interacting factor p43 associates with mammalian arginyl-tRNA synthetase but does not modify its tRNA aminoacylation properties.  |  Guigou, L., et al. 2004. Biochemistry. 43: 4592-600. PMID: 15078106
    5. Determinants in tRNA for activation of arginyl-tRNA synthetase: evidence that tRNA flexibility is required for the induced-fit mechanism.  |  Guigou, L. and Mirande, M. 2005. Biochemistry. 44: 16540-8. PMID: 16342945
    6. Two forms of human cytoplasmic arginyl-tRNA synthetase produced from two translation initiations by a single mRNA.  |  Zheng, YG., et al. 2006. Biochemistry. 45: 1338-44. PMID: 16430231
    7. Cloning and characterization of cDNA encoding a human arginyl-tRNA synthetase.  |  Girjes, AA., et al. 1995. Gene. 164: 347-50. PMID: 7590355
    8. Cloning and analysis of a cDNA encoding mammalian arginyl-tRNA synthetase, a component of the multisynthetase complex with a hydrophobic N-terminal extension.  |  Lazard, M. and Mirande, M. 1993. Gene. 132: 237-45. PMID: 8224869
    9. Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein.  |  Quevillon, S., et al. 1999. J Mol Biol. 285: 183-95. PMID: 9878398

    Ordering Information

    Product NameCatalog #UNITPriceQtyFAVORITES

    ArgRS Antibody (ZB-12)

    sc-100990
    200 µl ascites
    $333.00

    What is the concentration of sc-100990: ArgRS (ZB-12) monoclonal antibody?

    Asked by: Professor Griffin
    Thank you for your question. The concentration of ArgRS (ZB-12): sc-100990 has not been characterized. This antibody is provided as 200 µl of ascites
    Answered by: Technical Support
    Date published: 2017-03-24
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    Rated 5 out of 5 by from Good for Western BlotAntibody detects a band at the expected molecular weight of complexed ArgRS in A-431 whole cell lysate. -SCBT QC
    Date published: 2023-09-14
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    ArgRS Antibody (ZB-12) is rated 4.5 out of 5 by 2.
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