| Name | Mouse IL-21 |
|---|---|
| Supplier | ABBIOTEC |
| Catalog | 600371 |
| Category | Protein |
| Prices | $250.00 |
| Sizes | 10 µg |
| Species Reactivities | Mouse |
| Nature | Recombinant |
| Source | E. coli. Endotoxin level as measured by LAL is <0.05ng/ug or <0.5EU/ug. |
| Purity | Purity > 95% as determined by RP-HPLC and reducing and non-reducing SDS-PAGE. Protein Content determined by UV spectroscopy at 280 nm and analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard. |
| Bioactivity | The activity is determined by a dose-dependent proliferation of lymphocytes co-stimulated with anti-CD3? and is typically 2-50 ng/mL. Specific activity: 5 x 10e5 units/mg |
| Gene | Retnlb |
| Sequence | MHKSSPQGPD RLLIRLRHLI DIVEQLKIYE NDLDPELLSA PQDVKGHCEH AAFACFQKAK LKPSNPGNNK TFIIDLVAQL RRRLPARRGG KKQKHIAKCP SCDSYEKRTP KEFLERLKWL LQKMIHQHLS |
| Description | Interleukin-21 (IL-21) is a member of the common gamma-chain family of cytokines (includes IL-2, IL-4, IL-7, IL-9, IL-13, and IL-15) and is expressed by activated CD4+ T cells. IL-21 has a private receptor known as IL-21R, which is expressed on T, B, and NK cells. Within the B cell lineage, IL-21 regulates IgG1 production and cooperates with IL-4 for the production of multiple Ab classes in vivo. Initial studies have demonstrated that IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, natural killer, and dendritic cells. Mouse IL-21 is produced in E.coli. Recombinant mouse IL-21 is a non-glycosylated protein, containing 130 amino acids, with a total molecular weight of 15.1 kDa. |
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