| Name | Mouse NGF-beta |
|---|---|
| Supplier | ABBIOTEC |
| Catalog | 600207 |
| Category | Protein |
| Prices | $250.00 |
| Sizes | 20 µg |
| Species Reactivities | Mouse |
| Source | E. coli. Endotoxin level as measured by LAL is <0.01ng/ug or <0.1EU/ug. |
| Purity | Purity > 98% as determined by: Analysis by RP-HPLC and reducing and non-reducing SDS-PAGE. Protein Content determined by UV spectroscopy at 280 nm and analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard. |
| Bioactivity | b-NGF is fully biologically active when compared to standards. Activity was measured in a cell proliferation assay using a factor-dependent human erythroleukemic cell line, TF-1, the ED50 for this effect is typically 0.3 - 1 ng/ml. |
| Gene | Ngf |
| Sequence | MSSTHPVFHM GEFSVCDSVS VWVGDKTTAT DIKGKEVTVL AEVNINNSVF RQYFFETKCR ASNPVESGCR GIDSKHWNSY CTTTHTFVKA LTTDEKQAAW RFIRIDTACV CVLSRKATRR G |
| Description | Nerve Growth Factor (NGF) is the first of a series of neurotrophic factors that were found to influence the growth and differentiation of sympathetic and sensory neurons. It is comprised of alpha, beta, and gamma subunits. The beta subunit is responsible for its growth-stimulating activity. The synthesis of NGF in astrocytes is enhanced by various other cytokines: IL-1, TNF-alpha, PDGF and TGF-beta. Mouse beta-NGF produced in the submaxillary gland is a homodimer consisting of two identical 120 amino acid non-glycosylated polypeptide chains with a MW of 13,471 Da each. |
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