| Name | anti-IL2RA immunotoxin RFT5 (scFv)-RTA |
|---|---|
| Supplier | Creative Biolabs |
| Catalog | AGTO-L027R |
| Applications | Cytotoxic Assay FA |
| Species Reactivities | Human |
| SwissProt/Accession | P01589 |
| Gene | IL2RA |
| Description | This immunotoxin was achieved by conjugating/fusing the Anti-IL2RA scFv to ricin A chain. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to Hodgkin's lymphoma cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of Hodgkin's lymphoma. |
| Supplier Page | Shop |