| Name | Anti-ERBB2 immunotoxin 4D5 (scFv)-RTA |
|---|---|
| Supplier | Creative Biolabs |
| Catalog | AGTO-G022R |
| Applications | Cytotoxic Assay FA |
| Species Reactivities | Human |
| SwissProt/Accession | P04626 |
| Gene | ERBB2 |
| Description | This immunotoxin was achieved by conjugating/fusing the Anti-ERBB2 scFv to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of SK-OV-3 tumor xenografts. |
| Supplier Page | Shop |