| Name | Anti-ERBB2 immunotoxin 4D5 (scFv)-Gel |
|---|---|
| Supplier | Creative Biolabs |
| Catalog | AGTO-G022G |
| Applications | Cytotoxic Assay FA |
| Species Reactivities | Human |
| SwissProt/Accession | P04626 |
| Gene | ERBB2 |
| Description | This immunotoxin was achieved by conjugating/fusing the Anti-ERBB2 scFv to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then, gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treating SK-OV-3 tumor xenografts. |
| Supplier Page | Shop |