| Name | Anti-EGFR immunotoxin D2C7 (IgG)-Gel |
|---|---|
| Supplier | Creative Biolabs |
| Catalog | AGTO-G019G |
| Applications | Cytotoxic Assay FA |
| Species Reactivities | Human |
| SwissProt/Accession | P00533 |
| Gene | EGFR |
| Description | This immunotoxin was achieved by conjugating/fusing the Anti-EGFR monoclonal antibody to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then, gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treating brain tumors. |
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