| Name | IGFBP-1 protein |
|---|---|
| Supplier | Biorbyt |
| Catalog | orb97788 |
| Category | Protein |
| Prices | $451.00 |
| Sizes | 20 μg |
| Species Reactivities | Human |
| Nature | Recombinant |
| Source | P08833 |
| Purity | > 95% pure by SDS-PAGE and RP-HPLC |
| Bioactivity | IC50: 100 ng/ml Inhibition of IGF-I stimulated proliferation of NUC-1 cells.IC50 1% serum: 300 ng/ml Inhibition of seruminduced stimulation of DNA synthesis in chick embryofibroblast primary cultures. |
| Endotoxin | Less than 0.1 ng/g (IEU/g) of IGFBP-1. |
| Gene | IGFBP1 |
| Description | IGFBP-1 protein.IGFBP-1 is one of the six homologous proteins that specifically bind insulin-like growth factors and modulate theirmitogenic and metabolic actions. The function of this protein is not completely defined. However, several studiesdemonstrate that it inhibits IGF binding to cell surface receptors and thereby inhibits IGF-mediated mitogenic andcell metabolic actions. Insulin Like Growth Factor BindingProtein modulate IGF activities by increasing their plasmahalf lives and by inhibiting or promoting the interactionsof IGF with receptors on certain target cells. In additionthese binding proteins provide a reservoir for IGF in pericellular spaces. Some IGFBPs also have stimulating effectsin vitro and some may inhibit the growth of cells.Recombinant human Insulin Like Growth Factor BindingProtein 1 is a single glycosylated polypeptide chain containing 218 amino acids and having a molecular mass of28.806 kDa.The IGFBP-1 is purified by proprietary chromatographictechniques. |
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