| Gene Symbol | LRP2 |
|---|---|
| Entrez Gene | 4036 |
| Alt Symbol | DBS, GP330 |
| Species | Human |
| Gene Type | protein-coding |
| Description | low density lipoprotein receptor-related protein 2 |
| Other Description | Heymann nephritis antigen homolog|LRP-2|calcium sensor protein|glycoprotein 330|low-density lipoprotein receptor-related protein 2|megalin |
| Swissprots | O00711 Q16215 P98164 |
| Accessions | AAC17129 AAX88965 AAY24266 CCQ43266 EAX11280 P98164 AK295005 BAG58066 AK302843 BAG64033 AY265357 AAP88585 AY265358 AAP88586 CD673312 DA200673 DA339827 DA401915 S73145 AAB30825 U04441 AAB02882 U33837 AAB41649 XM_011511183 XP_011509485 XM_011511184 XP_011509486 XM_011511185 XP_011509487 NM_004525 NP_004516 |
| Function | Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid- hormone and para-thyroid-hormone-related protein release. {ECO:0000250}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. Membrane, coated pit. |
| Tissue Specificity | Absorptive epithelia, including renal proximal tubules. |
| Top Pathways | Hedgehog signaling pathway, Thyroid hormone synthesis |