| Gene Symbol | acrA |
|---|---|
| Entrez Gene | 945112 |
| Alt Symbol | ECK0457, JW0452, Mb, lir, mbl, mtcA, nbsA, sipB |
| Species | Escherichia coli |
| Gene Type | protein-coding |
| Description | multidrug efflux system |
| Other Description | - |
| Swissprots | P31223 Q2MBW4 P0AE06 |
| Accessions | AAC73565 NP_414996 |
| Function | AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm. {ECO:0000269|PubMed:9878415}. |
| Subcellular Location | Cell inner membrane {ECO:0000269|PubMed:15228545, ECO:0000269|PubMed:16079137}; Lipid- anchor {ECO:0000255|PROSITE-ProRule:PRU00303, ECO:0000269|PubMed:15228545, ECO:0000269|PubMed:16079137}. Note=An unlipidated version of this protein (directed to the periplasm by the OmpA signal sequence) functions normally. |
| Top Pathways | beta-Lactam resistance, Cationic antimicrobial peptide (CAMP) resistance |