| Gene Symbol | bsk |
|---|---|
| Entrez Gene | 44801 |
| Alt Symbol | BSK, Bsk, CG5680, D-JNK, D-junk, DBSK/JNK, DJNK, DJNK/bsk, Dmel\CG5680, JNK, JNK/SAPK, Jnk, Junk, SAPKa, dJNK, jnk, pJNK |
| Species | Drosophila |
| Gene Type | protein-coding |
| Description | basket |
| Other Description | CG5680-PB|CG5680-PE|CG5680-PF|JNK|JUN kinase|Jun N-terminal kinase|Jun NH2-terminal kinase|Jun-N-terminal kinase|Jun-kinase|bsk-PB|bsk-PE|bsk-PF|c-Jun N-terminal kinase|c-Jun aminoterminal kinase|c-Jun-N-terminal kinase|pJNK |
| Swissprots | Q94542 O01366 P92208 |
| Accessions | AAB48381 AAF52883 ACZ94220 ACZ94221 P92208 AY070865 AAL48487 AY122221 AAM52733 U49180 AAB97094 NM_001169459 NP_001162930 NM_001169461 NP_001162932 NM_164900 NP_723541 |
| Function | Responds to activation by environmental stress by phosphorylating a number of transcription factors, primarily components of AP-1 such as Jra and also the transcriptional repressor aop, and thus regulates transcriptional activity. Component of the immune response activated by bacterial infection, and is involved in wound healing and in dorsal closure, a morphogenetic movement during embryogenesis. Controls the expression of a phosphatase, puckered, at the edges of wounded epidermal tissue and in the dorsal epithelium during dorsal closure. {ECO:0000269|PubMed:10433922, ECO:0000269|PubMed:11784101, ECO:0000269|PubMed:8946915, ECO:0000269|PubMed:9224720}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. |
| Tissue Specificity | During gastrulation, expression is seen in cells undergoing morphogenetic movements. By stage 9 of embryonic development, expression is ubiquitous. At stages 12-14, expression occurs in epidermis and central nervous system. At stage 15, expression is restricted to ventral nerve cord, brain and some peripheral neurons. In larvae, expression is seen in all imaginal disks, with highest levels in wing and eye disks, and in the CNS. Adults express the protein in fat body and hemocytes. {ECO:0000269|PubMed:8946915, ECO:0000269|PubMed:8946916}. |
| Top Pathways | Wnt signaling pathway, Protein processing in endoplasmic reticulum, Hippo signaling pathway - fly |