Gene Symbol | HIST2H4A |
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Entrez Gene | 8370 |
Alt Symbol | FO108, H4, H4/n, H4F2, H4FN, HIST2H4 |
Species | Human |
Gene Type | protein-coding |
Description | histone cluster 2, H4a |
Other Description | H4 histone family, member N|H4 histone, family 2|histone 2, H4a|histone H4|histone IV, family 2 |
Swissprots | Q6NWP7 P62805 Q6DRA9 A2VCL0 Q6FGB8 |
Accessions | AAA52652 AAM83108 CAA24918 CAI12560 BC019846 BC093969 AAH93969 BC108260 BC112193 AAI12194 BC146448 AAI46449 BC153063 AAI53064 CR542172 CAG46969 NM_003548 NP_003539 |
Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
Subcellular Location | Nucleus. Chromosome. |
Top Pathways | Systemic lupus erythematosus, Viral carcinogenesis, Alcoholism |
Anti-Histone H4R3me2s antibody produced in rabbit - SAB4300870 from Sigma-Aldrich
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Anti-Histone H4R3me1 antibody produced in rabbit - SAB4300869 from Sigma-Aldrich
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Anti-Histone H4K20me1 antibody produced in rabbit - SAB4300871 from Sigma-Aldrich
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Anti-Histone H4K20me2 antibody produced in rabbit - SAB4300872 from Sigma-Aldrich
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Anti-Histone H4R3me2a antibody produced in rabbit - SAB4300868 from Sigma-Aldrich
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Anti-Histone H4K20me3 antibody produced in rabbit - SAB4300873 from Sigma-Aldrich
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Histone H4K12ac (acetyl Lys12) antibody - GTX88003 from GeneTex
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Histone H4K16ac (acetyl Lys16) antibody - GTX88004 from GeneTex
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Histone H4K5ac (acetyl Lys5) antibody - GTX88005 from GeneTex
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H4-K20 Antibody - N-terminal region (OAAB16455) - OAAB16455 from Aviva Systems Biology
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HIST1H4A Antibody - C-terminal region (OAAB18107) - OAAB18107 from Aviva Systems Biology
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MonoMethyl-Histone H4-K20 Polyclonal Antibody - A2370 from ABclonal
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DiMethyl-Histone H4-K20 Polyclonal Antibody - A2371 from ABclonal
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TriMethyl-Histone H4-K20 Polyclonal Antibody - A2372 from ABclonal
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Asymmetric DiMethyl-Histone H4-R3 Polyclonal Antibody - A2376 from ABclonal
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MonoMethyl-Histone H4-R3 Polyclonal Antibody - A3158 from ABclonal
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Symmetric DiMethyl-Histone H4-R3 Polyclonal Antibody - A3159 from ABclonal
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Acetyl-Histone H4-K8 Polyclonal Antibody - A7258 from ABclonal
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Rabbit Anti-HIST1H4A (C-term) - 102-14939 from RayBiotech
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Rabbit Anti-Human Me2-H4(K20) - 102-15514 from RayBiotech
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Rabbit Anti-H4-K20 (N-term) - 102-16551 from RayBiotech
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Anti-Histone H4R3me2a antibody - STJ23973 from St John's Laboratory Ltd
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Anti-Histone H4K20me3 antibody - STJ23972 from St John's Laboratory Ltd
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Anti-Histone H4K20me2 antibody - STJ23971 from St John's Laboratory Ltd
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Anti-Histone H4K20me1 antibody - STJ23970 from St John's Laboratory Ltd
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