| Gene Symbol | ST3GAL3 |
|---|---|
| Entrez Gene | 6487 |
| Alt Symbol | EIEE15, MRT12, SIAT6, ST3GALII, ST3GalIII, ST3N |
| Species | Human |
| Gene Type | protein-coding |
| Description | ST3 beta-galactoside alpha-2,3-sialyltransferase 3 |
| Other Description | CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase|Gal beta-1,3(4)GlcNAc alpha-2,3 sialyltransferase|ST3Gal III|alpha 2,3-ST 3|alpha 2,3-sialyltransferase III|alpha-2,3-sialyltransferase II|mental retardation, non-syndromic, autosomal recessive, 12|sialyltransferase 6 (N-acetyllacosaminide alpha 2,3-sialyltransferase) |
| Swissprots | Q86US2 Q8IX46 Q5T4Y4 Q5T4X8 Q8IX58 Q8IX55 Q8IX48 Q8IX41 Q8IX45 Q5T4X7 Q86US0 Q86UR7 Q8IX56 Q86UR6 D3DPX8 Q8IX49 Q86UR9 Q8IX47 Q8IX53 Q5T4W9 Q8IX50 Q5T4X0 Q5T4X9 Q8IX52 Q8IX51 Q86UR8 Q5T4Y3 Q5T4Y2 Q8IX42 Q5T4Y0 Q8IX43 Q8IX57 A9Z1W2 Q11203 Q86US1 Q8IX54 Q8IX44 |
| Accessions | CAT03463 EAX07082 EAX07083 EAX07084 Q11203 AA478788 AF425851 AAO13859 AF425852 AAO13860 AF425853 AAO13861 AF425854 AAO13862 AF425855 AAO13863 AF425856 AAO13864 AF425857 AAO13865 AF425858 AAO13866 AF425859 AAO13867 AF425860 AAO13868 AF425861 AAO13869 AF425862 AAO13870 AF425863 AAO13871 AF425864 AAO13872 AF425865 AAO13873 AF425866 AAO13874 AF425867 AAO13875 AF425868 AAO13876 AF425869 AAO13877 AK301829 BAG63274 AK310265 AY051143 AAL14347 AY167992 AAO38806 AY167993 AAO38807 AY167994 AAO38808 AY167995 AAO38809 AY167996 AAO38810 AY167997 AAO38811 AY167998 AAO38812 BC050380 AAH50380 HQ448581 ADQ33059 L23768 AAA35778 XM_006710825 XP_006710888 XM_006710826 XP_006710889 XM_006710827 XP_006710890 XM_006710828 XP_006710891 XM_006710829 XP_006710892 XM_011541972 XP_011540274 XM_011541973 XP_011540275 XM_011541974 XP_011540276 XM_011541975 XP_011540277 XM_011541976 XP_011540278 XM_011541977 XP_011540279 XM_011541978 XP_011540280 XM_011541979 XP_011540281 XM_011541980 XP_011540282 XM_011541981 XP_011540283 XM_011541982 XP_011540284 XM_011541983 XP_011540285 XM_011541984 XP_011540286 XM_011541985 XP_011540287 XM_011541986 XP_011540288 XM_011541987 XP_011540289 XM_011541988 XP_011540290 XM_011541989 XP_011540291 XM_011541990 XP_011540292 XR_946742 XR_946743 XR_946744 XR_946745 NM_001270459 NP_001257388 NM_001270460 NP_001257389 NM_001270461 NP_001257390 NM_001270462 NP_001257391 NM_001270463 NP_001257392 NM_001270464 NP_001257393 NM_001270465 NP_001257394 NM_001270466 NP_001257395 NM_006279 NP_006270 NM_174963 NP_777623 NM_174964 NP_777624 NM_174965 NP_777625 NM_174966 NP_777626 NM_174967 NP_777627 NM_174968 NP_777628 NM_174969 NP_777629 NM_174970 NP_777630 NM_174971 NP_777631 NR_073016 NR_073017 NR_073018 NR_073019 NR_073020 NR_073021 NR_073023 NM_174972 |
| Function | Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta- 1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- or NeuAc-alpha- 2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3- GalNAc (By similarity). {ECO:0000250}. |
| Subcellular Location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid. |
| Tissue Specificity | Highly expressed in adult skeletal muscle and in all fetal tissues examined and to a much lesser extent in placenta, lung and liver. |
| Top Pathways | Other types of O-glycan biosynthesis, Glycosaminoglycan biosynthesis - keratan sulfate, Glycosphingolipid biosynthesis - lacto and neolacto series |