| Gene Symbol | acrB |
|---|---|
| Entrez Gene | 945108 |
| Alt Symbol | ECK0456, JW0451, acrE |
| Species | Escherichia coli |
| Gene Type | protein-coding |
| Description | multidrug efflux system protein |
| Other Description | - |
| Swissprots | P31224 Q2MBW5 |
| Accessions | AAC73564 NP_414995 |
| Function | AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. {ECO:0000269|PubMed:16915237, ECO:0000269|PubMed:16946072, ECO:0000269|PubMed:17194213, ECO:0000269|PubMed:23010927}. |
| Subcellular Location | Cell inner membrane {ECO:0000269|PubMed:15228545, ECO:0000269|PubMed:16079137}; Multi- pass membrane protein {ECO:0000269|PubMed:15228545, ECO:0000269|PubMed:16079137}. |
| Top Pathways | beta-Lactam resistance, Cationic antimicrobial peptide (CAMP) resistance |