| Gene Symbol | GPAA1 |
|---|---|
| Entrez Gene | 8733 |
| Alt Symbol | GAA1, hGAA1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | glycosylphosphatidylinositol anchor attachment 1 |
| Other Description | GAA1 protein homolog|GPAA1P anchor attachment protein 1 homolog|GPI anchor attachment protein 1|GPI transamidase subunit|anchor attachment protein 1 (Gaa1p, yeast) homolog|glycophosphatidylinositol anchor attachment 1|glycosylphosphatidylinositol anchor attachment 1 protein|glycosylphosphatidylinositol anchor attachment protein 1 homolog |
| Swissprots | Q9UQ31 O43292 Q9NSS0 |
| Accessions | BAA82587 BAA82590 CAH05399 EAW82161 EAW82162 EAW82163 EAW82164 EAW82165 O43292 AB002135 BAA82588 AB006969 BAA24035 AK312759 BAG35625 AL157437 CAB75660 BC003171 AAH03171 BC004129 AAH04129 BC006383 AAH06383 DQ895039 ABM85965 EU176312 ABW03763 NM_003801 NP_003792 |
| Function | Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate. {ECO:0000269|PubMed:9468317}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:11483512}; Multi-pass membrane protein {ECO:0000269|PubMed:11483512}. |
| Tissue Specificity | Ubiquitously expressed in fetal and adult tissues. Expressed at higher levels in fetal tissues than adult tissues. {ECO:0000269|PubMed:9468317}. |
| Top Pathways | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis |