| Gene Symbol |
URM1
|
| Entrez Gene |
100860803
|
| Alt Symbol |
-
|
| Species |
Goat
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin related modifier 1
|
| Other Description |
CG33276-PA-like protein|Ubiquitin-related modifier 1 homolog|ubiquitin-related modifier 1
|
| Swissprots |
A9YUB5
|
| Accessions |
A9YUB5 EU295697 ABY21278 XM_005687191 XP_005687248 NM_001285664 NP_001272593
|
| Function |
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2- thiolation reaction by being thiocarboxylated (-COSH) at its C- terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates. {ECO:0000255|HAMAP- Rule:MF_03048}.
|
| Subcellular Location |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03048}.
|
| Top Pathways |
Sulfur relay system
|