| Gene Symbol | yki |
|---|---|
| Entrez Gene | 37851 |
| Alt Symbol | CG4005, Dmel\CG4005, YAP, YKI, Yki, yap |
| Species | Drosophila |
| Gene Type | protein-coding |
| Description | yorkie |
| Other Description | CG4005-PD|CG4005-PF|CG4005-PG|yki-PD|yki-PF|yki-PG |
| Swissprots | A2RVH0 Q0E8X1 A2RVH4 Q95TU5 Q9W1B6 Q7KVG6 Q45VV3 |
| Accessions | AAF47156 AAM68300 ABI31113 Q45VV3 NM_001043103 NP_001036568 NM_138035 NP_611879 NM_166657 NP_726414 |
| Function | Transcriptional coactivator which is the critical downstream regulatory target in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Regulates the expression of G1/S-specific cyclin-E (CycE) and apoptosis 1 inhibitor (th), thereby promoting cell proliferation and inhibiting apoptosis. Required for transcriptional activity of scalloped (sd) in wing imaginal disks. Induces expression of e |
| Subcellular Location | Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. sd promotes its nuclear localization. 14-3-3epsilon and 14-3-3zeta and wts inhibit its nuclear locaization. |
| Top Pathways | Hippo signaling pathway - fly |