| Gene Symbol | BDNF |
|---|---|
| Entrez Gene | 627 |
| Alt Symbol | ANON2, BULN2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | brain-derived neurotrophic factor |
| Other Description | abrineurin|neurotrophin |
| Swissprots | D3DQZ2 A7LA92 Q598Q1 A7LA85 Q9BYY7 Q6YNR3 Q9UC24 P23560 Q6YNR2 Q6DN19 |
| Accessions | AAA51820 AAA96140 AAG47514 AAO15434 EAW68274 EAW68275 EAW68276 EAW68277 EAW68278 EAW68279 P23560 AB038670 BAB55545 AB038671 BAB55546 AB038672 BAB55547 AB038673 BAB55548 AB038674 BAB55549 AF400438 AAK92487 AK289763 BAF82452 AK289853 BAF82542 AY054392 AAL23557 AY054393 AAL23558 AY054394 AAL23559 AY054395 AAL23560 AY054396 AAL23561 AY054397 AAL23562 AY054398 AAL23563 AY054399 AAL23564 AY054400 AAL23565 AY054406 AAL23571 AY442188 AAR14686 AY656701 AAT74399 BC029795 AAH29795 CX751420 DQ250642 ABB51155 DQ890811 ABM81737 DQ893966 ABM84892 EF674517 ABS29021 EF674518 ABS29022 EF674519 ABS29023 EF674520 ABS29024 EF674521 ABS29025 EF689009 ABS32249 EF689010 ABS32250 EF689011 ABS32251 EF689012 ABS32252 EF689013 ABS32253 EF689014 ABS32254 EF689015 ABS32255 EF689016 ABS32256 EF689017 ABS32257 EF689018 ABS32258 EF689019 ABS32259 EF689020 ABS32260 EF689021 ABS32261 KC855559 AGR50950 KP229412 AKB90516 M61176 AAA69805 X60201 CAA42761 X91251 CAA62632 XM_011520280 XP_011518582 NM_001143805 NP_001137277 NM_001143806 NP_001137278 NM_001143807 NP_001137279 NM_001143808 NP_001137280 NM_001143809 NP_001137281 NM_001143810 NP_001137282 NM_001143811 NP_001137283 NM_001143812 NP_001137284 NM_001143813 NP_001137285 NM_001143814 NP_001137286 NM_001143816 NP_001137288 NM_001709 NP_001700 NM_170731 NP_733927 NM_170732 NP_733928 NM_170733 NP_733929 NM_170734 NP_733930 NM_170735 NP_733931 NM_001143815 |
| Function | During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. {ECO:0000269|PubMed:12553913}. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta. {ECO:0000269|PubMed:17629449}. |
| Top Pathways | Huntington's disease, MAPK signaling pathway, Neurotrophin signaling pathway, Cocaine addiction, Alcoholism |