| Gene Symbol |
MSH3
|
| Entrez Gene |
4437
|
| Alt Symbol |
DUP, MRP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mutS homolog 3
|
| Other Description |
DNA mismatch repair protein Msh3|divergent upstream protein|hMSH3|mismatch repair protein 1
|
| Swissprots |
Q6PJT5 Q86UQ6 A1L482 A6NMM6 A1L480 Q92867 P20585
|
| Accessions |
AAP13535 BAD27111 EAW95861 EAW95862 P20585 AA601983 AI817671 AK289856 BAF82545 BC004177 BC011817 AAH11817 BC017273 BC098436 BC130434 AAI30435 BC130436 AAI30437 BF593920 J04810 AAB47281 U61981 AAB06045 NM_002439 NP_002430
|
| Function |
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion- deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
|
| Top Pathways |
Mismatch repair, Colorectal cancer
|