AURKC
| Gene Symbol | AURKC |
|---|---|
| Entrez Gene | 6795 |
| Alt Symbol | AIE2, AIK3, ARK3, AurC, SPGF5, STK13, aurora-C |
| Species | Human |
| Gene Type | protein-coding |
| Description | aurora kinase C |
| Other Description | ARK-3|aurora 3|aurora-related kinase 3|aurora/IPL1-related kinase 3|aurora/IPL1/EG2 protein 2|serine/threonine kinase 13 (aurora/IPL1-like)|serine/threonine-protein kinase 13|serine/threonine-protein kinase aurora-C |
| Swissprots | Q9UPK5 Q6DLZ0 O75442 Q9UQB9 Q6AZY8 O60681 |
| Accessions | EAW72485 EAW72486 Q9UQB9 AB017332 BAA76292 AF054621 AAC25955 AF059681 AAC77369 AK301886 BAG63318 AY661554 AAT64422 AY714054 AAU04399 BC075064 AAH75064 BX092186 EU668345 ACF94498 XR_430209 NM_001015878 NP_001015878 NM_001015879 NP_001015879 NM_003160 NP_003151 |
| Function | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. {ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:15499654, ECO:0000269|PubMed:15670791, ECO:0000269|PubMed:15938719, ECO:0000269|PubMed:21493633, ECO:0000269|PubMed:21531210}. |
| Subcellular Location | Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis. |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase. {ECO:0000269|PubMed:15670791}. |
Active human IPL-1/STK13/Aurora C full length protein - ab63177 from Abcam
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Human IPL-1/STK13/Aurora C full length protein - ab133139 from Abcam
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Human IPL-1/STK13/Aurora C full length protein - ab152713 from Abcam
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Human IPL-1/STK13/Aurora C protein fragment - ab152714 from Abcam
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AURKC / Aurora C Antibody Blocking Peptide - LS-E19354 from LifeSpan Bioscience
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AURKC / Aurora C Antibody Blocking Peptide - LS-E27279 from LifeSpan Bioscience
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AURKC / Aurora C Antibody Blocking Peptide - LS-E8594 from LifeSpan Bioscience
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AURKC / Aurora C Antibody Blocking Peptide - LS-E8596 from LifeSpan Bioscience
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AURKC / Aurora C Antibody Blocking Peptide - LS-E8595 from LifeSpan Bioscience
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Recombinant Human Aurora C Protein - H00006795-P01 from Novus Biologicals
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Recombinant Human Aurora C Protein - H00006795-Q01 from Novus Biologicals
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Aurora C Recombinant Protein - P4653 from Novus Biologicals
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Aurora C Peptide - P2083 from Novus Biologicals
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Aurora-C-Antibody-Center-Blocking-Peptide - BP7000g from Abgent, a WuXi AppTec company
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Aurora-C-Antibody-N-term-G11-Blocking-Peptide - BP7000f from Abgent, a WuXi AppTec company
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Aurora-C-Antibody-N-term-M1-Blocking-Peptide - BP7000e from Abgent, a WuXi AppTec company
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Aurora C blocking peptide - GTX88135-PEP from GeneTex
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AURKC Blocking Peptide - 33R-9386 from Fitzgerald
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IPL-1/STK13/Aurora C Peptide - AC21-2099-P from Abcore
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Aurora kinase C - H00006795-P01-10 from Acris Antibodies
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Aurora kinase C - H00006795-P01-25 from Acris Antibodies
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Aurora kinase C - H00006795-Q01-10 from Acris Antibodies
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Aurora kinase C - H00006795-Q01-25 from Acris Antibodies
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Aurora kinase C - P4653 from Acris Antibodies
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Aurora kinase C - P5686 from Acris Antibodies
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