AURKC

Gene Symbol AURKC
Entrez Gene 6795
Alt Symbol AIE2, AIK3, ARK3, AurC, SPGF5, STK13, aurora-C
Species Human
Gene Type protein-coding
Description aurora kinase C
Other Description ARK-3|aurora 3|aurora-related kinase 3|aurora/IPL1-related kinase 3|aurora/IPL1/EG2 protein 2|serine/threonine kinase 13 (aurora/IPL1-like)|serine/threonine-protein kinase 13|serine/threonine-protein kinase aurora-C
Swissprots Q9UPK5 Q6DLZ0 O75442 Q9UQB9 Q6AZY8 O60681
Accessions EAW72485 EAW72486 Q9UQB9 AB017332 BAA76292 AF054621 AAC25955 AF059681 AAC77369 AK301886 BAG63318 AY661554 AAT64422 AY714054 AAU04399 BC075064 AAH75064 BX092186 EU668345 ACF94498 XR_430209 NM_001015878 NP_001015878 NM_001015879 NP_001015879 NM_003160 NP_003151
Function Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. {ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:15499654, ECO:0000269|PubMed:15670791, ECO:0000269|PubMed:15938719, ECO:0000269|PubMed:21493633, ECO:0000269|PubMed:21531210}.
Subcellular Location Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis.
Tissue Specificity Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase. {ECO:0000269|PubMed:15670791}.

ARK-3 (N-19) - sc-47800 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Aurora B + C antibody - ab196873 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Aurora B + C antibody (ab196873) at 1/500 dilutionLane 1 : 293 cell extractLane 2 : HeLa cell extractLane 3 : HepG2 cell extractLane 4 : HepG2 cell extract with synthesized peptide

Anti-IPL-1/STK13/Aurora C antibody - ab38299 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
IHC image of IPL-1/STK13/Aurora C staining in Human normal testis formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab38299, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-IPL-1/STK13/Aurora C antibody - ab198705 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human brain tissue labeling IPL-1/STK13/Aurora C with ab198705 at 1/15 dilution.

Anti-IPL-1/STK13/Aurora C antibody - ab38298 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IPL-1/STK13/Aurora C antibody (ab38298) at 1/100 dilutionLane 1 : 293 cell lysate expressing Flag tag Lane 2 : 293 cell lysate expressing Flag tagged Aurora ALane 3 : 293 cell lysate expressing Flag tagged Aurora BLane 4 : 293 cell lysate expressing Flag tagged Aurora C

Anti-IPL-1/STK13/Aurora C antibody - ab38297 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IPL-1/STK13/Aurora C antibody (ab38297)Lane 1 : 293 cell lysate expressing Flag tagLane 2 : 293 cell lysate expressing Flag tagged Aurora ALane 3 : 293 cell lysate expressing Flag tagged Aurora BLane 4 : 293 cell lysate expressing Flag tagged Aurora C

Anti-IPL-1/STK13/Aurora C antibody - ab99492 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-IPL-1/STK13/Aurora C antibody (ab99492) at 1.5 µg/ml + Human Testis lysate at 35 µgdeveloped using the ECL technique

Anti-IPL-1/STK13/Aurora C antibody - ab172143 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-IPL-1/STK13/Aurora C antibody (ab172143) at 1 µg/mlLane 1 : IPL-1/STK13/Aurora C transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.SecondaryGoat anti-Mouse IgGdeveloped using the ECL technique

Anti-IPL-1/STK13/Aurora C antibody [4F7] - ab113937 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4F7
All lanes : Anti-IPL-1/STK13/Aurora C antibody [4F7] (ab113937) at 1/500 dilutionLane 1 : HEK293T cell lysate, transfected with pCMV6-ENTRY controlLane 2 : HEK293T cell lysate, transfected with pCMV6-ENTRY IPL-1/STK13/Aurora CLysates/proteins at 5 µg per lane.

Anti-IPL-1/STK13/Aurora C antibody [EP1011Y] - ab46783 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1011Y
Anti-IPL-1/STK13/Aurora C antibody [EP1011Y] (ab46783) at 1/1000 dilution + HepG2 lysate at 10 µgSecondarygoat anti rabbit HRP at 2000

Anti-AURKC / Aurora C Antibody (aa5-20) - LS-C47418 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-AURKC / Aurora C Antibody (Internal) - LS-C12056 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AURKC / Aurora C Antibody (N-Terminus, AP) - LS-C275324 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AURKC / Aurora C Antibody (N-Terminus, APC) - LS-C275325 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AURKC / Aurora C Antibody (N-Terminus, Biotin) - LS-C275326 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AURKC / Aurora C Antibody (N-Terminus, Azide-free, HRP) - LS-C275327 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AURKC / Aurora C Antibody (N-Terminus, FITC) - LS-C275328 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AURKC / Aurora C Antibody (N-Terminus, PE) - LS-C275329 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AURKC / Aurora C Antibody (N-Terminus, AP) - LS-C275330 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AURKC / Aurora C Antibody (N-Terminus, APC) - LS-C275331 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AURKC / Aurora C Antibody (N-Terminus) - LS-C98894 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
The anti-Aurora C antibody is used in Western blot to detect Aurora C in lysates of 293 cells expressing Flag tag (lane 1), Flag-tagged Aurora A (lane 2), Flag-tagged Aurora B (lane 3) or Flag-tagged Aurora C (lane 4). In the immunofluorescence experiment, staining of HeLa cells expressing GFP-Aurora C is performed at different cellular mitotic stages with the anti-Aurora C antibody as primary antibody (column A), GFP fluorescence (column B), DAPI nuclear staining (column C), and anti-Aurora C merged to DAPI staining (column D). Data is kindly provided by Drs. K. Sasai and S. Sen from the University of Texas MD Anderson Cancer Center (Houston, TX).

Anti-AURKC / Aurora C Antibody (N-Terminus, Biotin) - LS-C275332 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AURKC / Aurora C Antibody (aa215-264) - LS-C111533 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
AURKC / Aurora-C antibody LS-C111533 Western blot of Fetal Pancreas lysate.

Anti-AURKC / Aurora C Antibody (N-Terminus, FITC) - LS-C275333 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AURKC / Aurora C Antibody (clone 4F7) - LS-C114650 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4F7
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY AURKC (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-AURKC.
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