| Gene Symbol | FBL |
|---|---|
| Entrez Gene | 2091 |
| Alt Symbol | FIB, FLRN, RNU3IP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | fibrillarin |
| Other Description | 34 kDa nucleolar scleroderma antigen|34-kD nucleolar scleroderma antigen|RNA, U3 small nucleolar interacting protein 1|histone-glutamine methyltransferase|rRNA 2'-O-methyltransferase fibrillarin |
| Swissprots | Q6IAT5 B5BUE8 O75259 P22087 Q9UPI6 |
| Accessions | AAC28913 AAD15623 EAW56925 P22087 AB451384 BAG70198 AI085380 AK296950 BAG59496 AK308649 BC015218 AAH15218 BC019260 AAH19260 BC019609 AAH19609 BG831506 BT006830 AAP35476 BT020144 AAV38946 CR457069 CAG33350 DQ892314 ABM83240 DQ895517 ABM86443 M59849 AAA52453 X56597 CAA39935 XM_005258651 XP_005258708 XM_011526623 XP_011524925 XM_011548798 XP_011547100 XM_011548799 XP_011547101 NM_001436 NP_001427 |
| Function | S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239). {ECO:0000269|PubMed:24352239}. |
| Subcellular Location | Nucleus, nucleolus {ECO:0000269|PubMed:14583623, ECO:0000269|PubMed:2026646, ECO:0000269|PubMed:2414294, ECO:0000269|PubMed:24352239}. Note=Fibrillar region of the nucleolus. |
| Top Pathways | Ribosome biogenesis in eukaryotes |