| Gene Symbol | PPT2 |
|---|---|
| Entrez Gene | 9374 |
| Alt Symbol | C6orf8, G14, PPT-2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | palmitoyl-protein thioesterase 2 |
| Other Description | S-thioesterase G14|VE-statin2|lysosomal thioesterase PPT2|palmitoyl-protein hydrolase 2 |
| Swissprots | Q5JQF0 G8JLE1 A8K9L4 Q5STJ6 Q99945 A2BFI2 Q5SSX6 Q9UMR5 Q5SSX4 A2ABC9 A2BFH7 A2BFH9 O14799 Q5JP14 A2ARM7 B0S868 Q5JP13 Q5STJ5 Q6FI80 Q5SSX5 Q5STJ4 A2ABD1 Q0P6K0 |
| Accessions | AAB47495 EAX03591 EAX03592 EAX03593 EAX03594 EAX03595 EAX03596 Q9UMR5 AF020543 AAB80730 AI472281 AL110128 CAB53659 AM392834 CAL37712 BC000955 BC001355 AAH01355 CR533546 CAG38577 DA153675 DA352776 DA918701 EU832333 ACE87590 EU832418 ACE86903 Y17958 CAB46981 NM_001204103 NP_001191032 NM_005155 NP_005146 NM_138717 NP_619731 NM_138934 |
| Function | Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S- thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins. {ECO:0000269|PubMed:10417332, ECO:0000269|PubMed:12855696, ECO:0000269|PubMed:9341199}. |
| Subcellular Location | Lysosome {ECO:0000269|PubMed:9341199}. |
| Tissue Specificity | Broadly expressed, with highest levels in skeletal muscle. {ECO:0000269|PubMed:9341199}. |
| Top Pathways | Lysosome, Fatty acid elongation, Fatty acid metabolism |