| Gene Symbol | RHOG |
|---|---|
| Entrez Gene | 391 |
| Alt Symbol | ARHG |
| Species | Human |
| Gene Type | protein-coding |
| Description | ras homolog family member G |
| Other Description | ras homolog gene family, member G (rho G)|rho-related GTP-binding protein RhoG |
| Swissprots | P35238 Q8NI04 P84095 |
| Accessions | EAX02575 EAX02576 EAX02577 P84095 AA424888 AF498974 AAM21121 AY563952 AAS75333 BC104177 AAI04178 BC104178 AAI04179 BI196968 BT019872 AAV38675 BX359696 CB125569 CR450335 CAG29331 CR542105 CAG46902 L11317 AAA60268 X61587 CAA43784 XM_005252916 XP_005252973 NM_001665 NP_001656 |
| Function | Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742, ECO:0000269|PubMed:20679435}. |
| Subcellular Location | Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. |
| Top Pathways | Bacterial invasion of epithelial cells, Salmonella infection |