| Gene Symbol | aPKC |
|---|---|
| Entrez Gene | 47594 |
| Alt Symbol | CG10261, CG30475, CG42783, DaPKC, Dmel\CG42783, Dmel_CG10261, Dmel_CG30475, PKCl, PKCzeta, a-PKC, aPKC-zeta, aPKCzeta, alphaPKCzeta, apkc, daPKC, dapkc, i, l(2)k06403, pkc-3, psu |
| Species | Drosophila |
| Gene Type | protein-coding |
| Description | atypical protein kinase C |
| Other Description | CG42783-PA|CG42783-PB|CG42783-PC|CG42783-PD|CG42783-PE|CG42783-PF|CG42783-PG|CG42783-PI|CG42783-PJ|CG42783-PK|CG42783-PL|CG42783-PM|aPKC-PA|aPKC-PB|aPKC-PC|aPKC-PD|aPKC-PE|aPKC-PF|aPKC-PG|aPKC-PI|aPKC-PJ|aPKC-PK|aPKC-PL|aPKC-PM|atypical PKC|atypical protein kinase|atypical-Protein kinase C|pschur |
| Swissprots | Q0E973 A1Z9X0 Q9GSZ3 Q0E971 Q0E972 Q8MT38 Q0E974 |
| Accessions | AAF58177 ABI31090 ABI31091 ABI31092 ABI31093 ABI31094 ADV37185 ADV37187 AGB93516 AGB93517 AGB93518 AGB93519 Q9V782 BT056247 ACL68694 NM_001043076 NP_001036541 NM_001043077 NP_001036542 NM_001043078 NP_001036543 NM_001043079 NP_001036544 NM_001043080 NP_001036545 NM_001202010 NP_001188939 NM_001202012 NP_001188941 NM_001274055 NP_001260984 NM_001274056 NP_001260985 NM_001274057 NP_001260986 NM_001274058 NP_001260987 NM_080153 NP_524892 |
| Function | Serine/threonine protein kinase which is required for apico-basal cell polarity in the germ line as well as in epithelial and neural precursor cells, for epithelial planar cell polarity and for cell proliferation. During oocyte development, required for the posterior translocation of oocyte specification factors and for the posterior establishment of the microtubule organizing center within the presumptive oocyte. Phosphorylates l(2)gl which restricts l(2)gl activity to the oocyte posterior and regulates posterior enrichment of par-1, leading to establishment of correct oocyte polarity. Essential for apical localization of l(2)gl and par-6 in neuroblasts and for exclusion of mira from the apical cortex. Phosphorylates baz which is required for targeting of baz to the postsynaptic region where it is involved in actin organization, and for apical exclusion of baz which is necessary for establishment of the apical/lateral border in epithelial cells. Phosphorylates yrt which prevents its p |
| Subcellular Location | Cytoplasm, cell cortex {ECO:0000269|PubMed:10995441, ECO:0000269|PubMed:11734648, ECO:0000269|PubMed:15302858, ECO:0000269|PubMed:18614576, ECO:0000269|PubMed:20434988, ECO:0000269|PubMed:24830287}. Apicolateral cell membrane {ECO:0000269|PubMed:10995441, ECO:0000269|PubMed:11734648, ECO:0000269|PubMed:15302858, ECO:0000269|PubMed:18614576, ECO:0000269|PubMed:20434988, ECO:0000269|PubMed:24830287}; Peripheral membrane protein {ECO:0000269|PubMed:10995441, ECO:0000269|PubMed:11734648, ECO:0000269|PubMed:15302858, ECO:0000269|PubMed:18614576, ECO:0000269|PubMed:20434988, ECO:0000269|PubMed:24830287}. Note=Cytoplasmic at interphase but localizes to the apical cell cortex during mitosis. {ECO:0000269|PubMed:10995441, ECO:0000269|PubMed:11734648, ECO:0000269|PubMed:15302858, ECO:0000269|PubMed:18614576, ECO:0000269|PubMed:20434988, ECO:0000269|PubMed:24830287}. |
| Tissue Specificity | Expressed in the testis. In spermatid cysts, localizes near the tips of spermatid flagellar axonemes (at protein level). Detectable in freshly laid eggs before onset of zygotic transcription so is deposited in the egg during oogenesis. At the cellular blastoderm stage, present in all cells except the pole cells. During gastrulation, strongly expressed in tissues undergoing morphogenetic movements such as invaginating mesoderm, proctodeum and cephalic furrow. Strongly expressed in neuroblasts. {ECO:0000269|PubMed:10995441, ECO:0000269|PubMed:24830287}. |
| Top Pathways | Endocytosis, Hippo signaling pathway - fly |