| Gene Symbol | Pla2g2d |
|---|---|
| Entrez Gene | 18782 |
| Alt Symbol | Splash, mGIID |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | phospholipase A2, group IID |
| Other Description | GIID sPLA2|PLA2IID|group IID secretory phospholipase A2|phosphatidylcholine 2-acylhydrolase 2D|sPLA2-IID|secretory-type PLA, stroma-associated homolog |
| Swissprots | Q9WVF6 Q9JLK0 Q3V4B8 |
| Accessions | AAF09019 EDL13277 EDL13278 Q9WVF6 AF112983 AAD51391 AF124374 AAD42773 AF169407 AAF42987 AF169408 AAF42988 AK004232 BAE43166 AK018005 BAB31033 AK157392 BAE34077 AK158364 BAE34473 AK171797 BAE42668 AK172367 BAE42967 BC111806 AAI11807 XM_006538657 XP_006538720 NM_011109 NP_035239 |
| Function | PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2- linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined. |
| Subcellular Location | Isoform 1: Secreted {ECO:0000305}. |
| Tissue Specificity | Expressed in several tissues including pancreas, spleen, thymus, skin, lung, and ovary. |
| Top Pathways | Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Ether lipid metabolism, Glycerophospholipid metabolism |