| Gene Symbol | PLA2G6 |
|---|---|
| Entrez Gene | 8398 |
| Alt Symbol | CaI-PLA2, GVI, INAD1, IPLA2-VIA, NBIA2, NBIA2A, NBIA2B, PARK14, PLA2, PNPLA9, iPLA2, iPLA2beta |
| Species | Human |
| Gene Type | protein-coding |
| Description | phospholipase A2, group VI (cytosolic, calcium-independent) |
| Other Description | 85 kDa calcium-independent phospholipase A2|85/88 kDa calcium-independent phospholipase A2|GVI PLA2|calcium-independent phospholipase A2|cytosolic, calcium-independent phospholipase A2|group VI phospholipase A2|iPLA2-beta|intracellular membrane-associated calcium-independent phospholipase A2 beta|neurodegeneration with brain iron accumulation 2|patatin-like phospholipase domain containing 9|patatin-like phospholipase domain-containing protein 9 |
| Swissprots | O60733 Q9UG29 O75645 A8K597 Q9UIT0 Q9Y671 B0QYE8 Q8N452 |
| Accessions | AAD30424 AAF34728 AAR92478 EAW60219 EAW60220 O60733 AF064594 AAC97486 AF102988 AAD41722 AF102989 AAD41723 AK001290 AK096521 BAG53314 AK128862 AK290825 BAF83514 AK291212 BAF83901 AK300459 BAH13289 AK308308 AL080187 CAB45768 BC034592 BC036742 AAH36742 BC051904 AAH51904 CR456543 CAG30429 CU013143 CAK54574 CU013431 CAK54873 XM_005261764 XP_005261821 XM_005261765 XP_005261822 XM_005261766 XP_005261823 XM_005261771 XP_005261828 XM_006724332 XP_006724395 XM_011530422 XP_011528724 XM_011530423 XP_011528725 XM_011530424 XP_011528726 XM_011530425 XP_011528727 XM_011530426 XP_011528728 XM_011530427 XP_011528729 XM_011530428 XP_011528730 XR_244390 XR_244392 XR_430411 XR_430412 XR_937937 XR_937938 XR_937939 XR_937940 NM_001004426 NP_001004426 NM_001199562 NP_001186491 NM_003560 NP_003551 |
| Function | Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pseudopods. |
| Subcellular Location | Isoform LH-iPLA2: Membrane; Peripheral membrane protein. Note=Recruited to the membrane-enriched pseudopod upon MCP1/CCL2 stimulation in monocytes. |
| Tissue Specificity | Four different transcripts were found to be expressed in a distinct tissue distribution. |
| Top Pathways | Fc gamma R-mediated phagocytosis, Vascular smooth muscle contraction, Inflammatory mediator regulation of TRP channels, Ether lipid metabolism, Glycerophospholipid metabolism |