| Gene Symbol | INPP5D |
|---|---|
| Entrez Gene | 3635 |
| Alt Symbol | SHIP, SHIP-1, SHIP1, SIP-145, hp51CN, p150Ship |
| Species | Human |
| Gene Type | protein-coding |
| Description | inositol polyphosphate-5-phosphatase, 145kDa |
| Other Description | SH2 domain-containing inositol 5'-phosphatase 1|inositol polyphosphate-5-phosphatase, 145kD|phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1|signaling inositol polyphosphate 5 phosphatase SIP-145|signaling inositol polyphosphate phosphatase SHIP II |
| Swissprots | Q92656 Q6P5A4 Q13544 O00145 Q13545 Q92835 Q9UE80 |
| Accessions | EAW71029 EAW71030 EAW71031 Q92835 AK298651 BAG60823 AK309644 AW503130 BC027960 BC062985 AAH62985 BC099920 AAH99920 BC113580 AAI13581 BC113582 AAI13583 BE247227 BM800110 U50040 AAC50453 U50041 AAC50454 U53470 AAD00081 U57650 AAB53573 U84400 AAB49680 X98429 CAA67071 XM_011511128 XP_011509430 XM_011511129 XP_011509431 XM_011548851 XP_011547153 XM_011548852 XP_011547154 NM_001017915 NP_001017915 NM_005541 NP_005532 |
| Function | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regul |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:10822173}. Membrane {ECO:0000269|PubMed:10822173}; Peripheral membrane protein {ECO:0000269|PubMed:10822173}. Note=Translocates to the plasma membrane when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Partly translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the FC-gamma-RIIB receptor (FCGR2B) or CD16/FCGR3. Tyrosine phosphorylation may also participate in membrane localization (By similarity). {ECO:0000250}. |
| Tissue Specificity | Specifically expressed in immune and hematopoietic cells. Expressed in bone marrow and blood cells. Levels vary considerably within this compartment. Present in at least 74% of immature CD34+ cells, whereas within the more mature population of CD33+ cells, it is present in only 10% of cells. Present in the majority of T-cells, while it is present in a minority of B-cells (at protein level). {ECO:0000269|PubMed:8769125, ECO:0000269|PubMed:8874179, ECO:0000269|PubMed:9058707, ECO:0000269|PubMed:9108392}. |
| Top Pathways | B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Inositol phosphate metabolism, Phosphatidylinositol signaling system |