| Gene Symbol |
PPP6C
|
| Entrez Gene |
5537
|
| Alt Symbol |
PP6, PP6C
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein phosphatase 6, catalytic subunit
|
| Other Description |
serine/threonine protein phosphatase catalytic subunit|serine/threonine-protein phosphatase 6 catalytic subunit
|
| Swissprots |
B7Z5K9 Q9UIC9 B2R5V6 Q5U0A2 O00743 B7Z2W9
|
| Accessions |
EAW87611 EAW87612 EAW87613 O00743 AA251321 AF035158 AAD45400 AK295190 BAH12005 AK295752 BAH12178 AK299087 BAH12945 AK312332 BAG35253 AK316527 BAH14898 BC006990 AAH06990 BT019708 AAV38514 CB250498 DB037210 DC307002 DC334216 DC369815 X92972 CAA63549 XM_011518847 XP_011517149 NM_001123355 NP_001116827 NM_001123369 NP_001116841 NM_002721 NP_002712
|
| Function |
Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. {ECO:0000269|PubMed:10227379, ECO:0000269|PubMed:17079228, ECO:0000269|PubMed:17568194, ECO:0000269|PubMed:9013334}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:16769727, ECO:0000269|PubMed:17568194}.
|
| Tissue Specificity |
Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen. {ECO:0000269|PubMed:16769727, ECO:0000269|PubMed:9013334}.
|