| Gene Symbol | SMPD2 |
|---|---|
| Entrez Gene | 6610 |
| Alt Symbol | ISC1, NSMASE, NSMASE1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) |
| Other Description | N-SMase|lyso-PAF-PLC|lyso-platelet-activating factor-phospholipase C|neutral sphingomyelinase|sphingomyelin phosphodiesterase 2 |
| Swissprots | O60906 Q9BWR3 Q5TED1 |
| Accessions | EAW48346 O60906 AJ222801 CAA10995 AK310148 AK313515 BAG36295 BC000038 AAH00038 CA314251 DA672570 DQ891879 ABM82805 HQ447883 ADQ32367 XM_005267109 XP_005267166 XM_011536079 XP_011534381 XR_942566 NM_003080 NP_003071 |
| Function | Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2- lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso- sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF. |
| Subcellular Location | Membrane; Multi-pass membrane protein. |
| Top Pathways | Sphingolipid signaling pathway, Sphingolipid metabolism |