| Gene Symbol | dco |
|---|---|
| Entrez Gene | 43673 |
| Alt Symbol | 0538/13, 0915/10, 1396/02, 1447/01, 1460/09, CG2048, CK1delta/epsilon, CK1epsilon, CKIepsilon, DBT, DBT/CK1epsilon, DCO, DCO/CKIe, Dbt, Dco, Dco/CK1, Dmel\CG2048, ck1epsilon, dCKIepsilon, dbt, dco-1, ddbt, l(3)S053813, l(3)S144701, l(3)dco, l(3)dco-1, l(3 |
| Species | Drosophila |
| Gene Type | protein-coding |
| Description | discs overgrown |
| Other Description | CG2048-PA|CG2048-PB|CG2048-PC|CG2048-PD|casein kinase I epsilon|casein kinase iepsilon|dco-PA|dco-PB|dco-PC|dco-PD|disc overgrown|double time|double-time|doubletime |
| Swissprots | Q0KHY4 O76324 Q9V462 A4V3P5 |
| Accessions | AAF27346 AAF57108 AAF57109 AAF57110 AGB96511 O76324 AF132558 AAD27857 NM_001276203 NP_001263132 NM_079863 NP_524602 NM_170535 NP_733414 NM_170536 NP_733415 |
| Function | Involved in circadian rhythms, viability and molecular oscillations of the clock genes period (per) and timeless (tim). Dbt reduces the stability and thus the accumulation of monomeric per proteins, probably through phosphorylation. No evident circadian oscillation is detected in head. {ECO:0000269|PubMed:10556065, ECO:0000269|PubMed:9674430, ECO:0000269|PubMed:9674431}. |
| Tissue Specificity | Expressed in photoreceptor cells of the eyes as well as in the region situated between the optic lobe and the central brain. {ECO:0000269|PubMed:10556065}. |
| Top Pathways | Wnt signaling pathway, Hedgehog signaling pathway, Hippo signaling pathway - fly |