| Gene Symbol | MYD88 |
|---|---|
| Entrez Gene | 4615 |
| Alt Symbol | MYD88D |
| Species | Human |
| Gene Type | protein-coding |
| Description | myeloid differentiation primary response 88 |
| Other Description | myeloid differentiation primary response gene (88)|myeloid differentiation primary response protein MyD88 |
| Swissprots | J3KPU4 B4DKH8 Q99836 B4DKU4 Q53XS7 B4DQ72 J3KQJ6 B4DQ60 J3KQ87 P78397 |
| Accessions | EAW64520 EAW64521 Q99836 AB446470 BAG55247 AK097983 AK124685 AK296570 BAG59190 AK296716 BAG59306 AK298650 BAG60822 AK298666 BAG60834 AK300051 BAG61860 AK300448 BAG62170 AK304676 BAG65448 AL832906 BC013589 AAH13589 BP242808 BP339466 BT007376 AAP36040 BX537602 DC350705 EU831951 ACE87392 EU832045 ACE86707 U70451 AAB49967 U84408 AAC50954 XM_005265172 XP_005265229 XM_006713170 XP_006713233 NM_001172566 NP_001166037 NM_001172567 NP_001166038 NM_001172568 NP_001166039 NM_001172569 NP_001166040 NM_002468 NP_002459 |
| Function | Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine. {ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:19506249, ECO:0000269|PubMed:9013863}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:15492225}. |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:8957090}. |
| Top Pathways | Herpes simplex infection, Legionellosis, Tuberculosis, Pertussis, Salmonella infection |